Experimental groups and hemodynamic parameters
| Mouse type . | Number of mice . | Number of venules . | Number of cells . | ||
|---|---|---|---|---|---|
| 200-500 s−1 . | 500-1000 s−1 . | 200-500 s−1 . | 500-1000 s−1 . | ||
| Wild-type | 5 | 11 | 11 | 110 | 110 |
| CD18 −/− | 2 | 5 | 5 | 50 | 50 |
| Mac-1 −/− | 9 | 16 | 7 | 159 | 70 |
| Mac-1 −/− + TIB217 | 6 | 9 | 9 | 90 | 90 |
| LFA-1 −/− | 8 | 16 | 24 | 160 | 239 |
| LFA-1 −/− + M1/70 | 8 | 17 | 16 | 164 | 154 |
| Mouse type . | Number of mice . | Number of venules . | Number of cells . | ||
|---|---|---|---|---|---|
| 200-500 s−1 . | 500-1000 s−1 . | 200-500 s−1 . | 500-1000 s−1 . | ||
| Wild-type | 5 | 11 | 11 | 110 | 110 |
| CD18 −/− | 2 | 5 | 5 | 50 | 50 |
| Mac-1 −/− | 9 | 16 | 7 | 159 | 70 |
| Mac-1 −/− + TIB217 | 6 | 9 | 9 | 90 | 90 |
| LFA-1 −/− | 8 | 16 | 24 | 160 | 239 |
| LFA-1 −/− + M1/70 | 8 | 17 | 16 | 164 | 154 |
| Mouse type . | Average diameter (μm) . | Centerline blood flow velocity (mm/s) . | Wall shear rate (s−1) . | |||
|---|---|---|---|---|---|---|
| 200-500 s−1 . | 500-1000 s−1 . | 200-500 s−1 . | 500-1000 s−1 . | 200-500 s−1 . | 500-1000 s−1 . | |
| Wild-type | 59 ± 7 | 41 ± 5 | 2.1 ± 0.1 | 2.8 ± 0.4 | 408 ± 20 | 692 ± 30 |
| CD18 −/− | 47 ± 4 | 41 ± 6 | 1.5 ± 0.2 | 2.8 ± 0.4 | 330 ± 40 | 730 ± 30 |
| Mac-1 −/− | 38 ± 2 | 42 ± 4 | 1.4 ± 0.1 | 2.7 ± 0.3 | 390 ± 20 | 690 ± 50 |
| Mac-1 −/− + TIB217 | 52 ± 5 | 39 ± 3 | 1.9 ± 0.2 | 2.7 ± 0.2 | 390 ± 20 | 740 ± 40 |
| LFA-1 −/− | 44 ± 3 | 41 ± 3 | 1.4 ± 0.1 | 2.6 ± 0.2 | 340 ± 20 | 680 ± 30 |
| LFA-1 −/− + M1/70 | 41 ± 3 | 44 ± 2 | 1.3 ± 0.1 | 3.0 ± 0.2 | 350 ± 20 | 700 ± 30 |
| Mouse type . | Average diameter (μm) . | Centerline blood flow velocity (mm/s) . | Wall shear rate (s−1) . | |||
|---|---|---|---|---|---|---|
| 200-500 s−1 . | 500-1000 s−1 . | 200-500 s−1 . | 500-1000 s−1 . | 200-500 s−1 . | 500-1000 s−1 . | |
| Wild-type | 59 ± 7 | 41 ± 5 | 2.1 ± 0.1 | 2.8 ± 0.4 | 408 ± 20 | 692 ± 30 |
| CD18 −/− | 47 ± 4 | 41 ± 6 | 1.5 ± 0.2 | 2.8 ± 0.4 | 330 ± 40 | 730 ± 30 |
| Mac-1 −/− | 38 ± 2 | 42 ± 4 | 1.4 ± 0.1 | 2.7 ± 0.3 | 390 ± 20 | 690 ± 50 |
| Mac-1 −/− + TIB217 | 52 ± 5 | 39 ± 3 | 1.9 ± 0.2 | 2.7 ± 0.2 | 390 ± 20 | 740 ± 40 |
| LFA-1 −/− | 44 ± 3 | 41 ± 3 | 1.4 ± 0.1 | 2.6 ± 0.2 | 340 ± 20 | 680 ± 30 |
| LFA-1 −/− + M1/70 | 41 ± 3 | 44 ± 2 | 1.3 ± 0.1 | 3.0 ± 0.2 | 350 ± 20 | 700 ± 30 |
Data are presented as mean ± SEM.