Cellular drug resistance of normal, nonleukemic PBMCs of children with and without Down syndrome
| Drug . | DS PBMC . | Non-DS PBMC . | RR . | P . | ||
|---|---|---|---|---|---|---|
| N . | Median LC50(P25-P75) . | N . | Median LC50 (P25-P75) . | |||
| Cytarabine | 8 | >2.5 | 11 | 0.97 | >2.6 | .03 |
| (2.29->2.5) | (0.56-2.45) | |||||
| Daunorubicin | 9 | 1.54 | 12 | 0.39 | 3.9 | .10 |
| (0.43->2.0) | (0.32-1.29) | |||||
| Etoposide | 9 | >50 | 12 | 35.0 | >1.4 | .68 |
| (22.2->50) | (25.3->50) | |||||
| 6-Thioguanine | 8 | >50 | 11 | >50 | 4-150 | .45 |
| (49.3->50) | (33.1->50) | |||||
| 2-Chloro- | 4 | >40 | 12 | 0.032 | >1250 | .22 |
| deoxyadenosine | (30.76->40) | (0.03-0.06) | ||||
| Prednisolone | 8 | >250 | 12 | >250 | 4-150 | .41 |
| (>250->250) | (>250->250) | |||||
| Vincristine | 9 | 41.03 | 11 | 32.47 | 1.3 | .30 |
| (34.33->50) | (18.31-47.79) | |||||
| L-Asparaginase | 8 | >10 | 12 | >10 | 4-150 | .41 |
| (>10->10) | (>10->10) | |||||
| 4-Hydroperoxy- | 6 | 4.00 | 12 | 1.49 | 2.7 | .13 |
| ifosfamide | (3.19-4.40) | (1.05-4.11) | ||||
| Amsacrine | 8 | 2.05 | 10 | 2.47 | 0.8 | .53 |
| (1.69-2.5) | (1.59-2.52) | |||||
| Drug . | DS PBMC . | Non-DS PBMC . | RR . | P . | ||
|---|---|---|---|---|---|---|
| N . | Median LC50(P25-P75) . | N . | Median LC50 (P25-P75) . | |||
| Cytarabine | 8 | >2.5 | 11 | 0.97 | >2.6 | .03 |
| (2.29->2.5) | (0.56-2.45) | |||||
| Daunorubicin | 9 | 1.54 | 12 | 0.39 | 3.9 | .10 |
| (0.43->2.0) | (0.32-1.29) | |||||
| Etoposide | 9 | >50 | 12 | 35.0 | >1.4 | .68 |
| (22.2->50) | (25.3->50) | |||||
| 6-Thioguanine | 8 | >50 | 11 | >50 | 4-150 | .45 |
| (49.3->50) | (33.1->50) | |||||
| 2-Chloro- | 4 | >40 | 12 | 0.032 | >1250 | .22 |
| deoxyadenosine | (30.76->40) | (0.03-0.06) | ||||
| Prednisolone | 8 | >250 | 12 | >250 | 4-150 | .41 |
| (>250->250) | (>250->250) | |||||
| Vincristine | 9 | 41.03 | 11 | 32.47 | 1.3 | .30 |
| (34.33->50) | (18.31-47.79) | |||||
| L-Asparaginase | 8 | >10 | 12 | >10 | 4-150 | .41 |
| (>10->10) | (>10->10) | |||||
| 4-Hydroperoxy- | 6 | 4.00 | 12 | 1.49 | 2.7 | .13 |
| ifosfamide | (3.19-4.40) | (1.05-4.11) | ||||
| Amsacrine | 8 | 2.05 | 10 | 2.47 | 0.8 | .53 |
| (1.69-2.5) | (1.59-2.52) | |||||
LC50 values are given in μg/mL.
RR, the median LC50 value for DS PBMC, divided by the median LC50 value for non-DS PBMC.
P value derived from 2-tailed Mann-Whitney Utest.
L-asparaginase is given in IU/mL (IU/L), not in μg/mL (μM).
N indicates number of samples tested; P25-P75, 25th and 75th percentiles.
RR could not be calculated because both median LC50 values exceeded the maximum concentration.