Table 3. Cellular drug resistance in DS... | American Society of Hematology

Table 3.

Cellular drug resistance in DS ALL versus non-DS BCP-ALL

Drug	DS ALL		Non-DS BCP-ALL		RR	P
Drug	N	Median (P25-P75)	N	Median (P25-P75)	RR	P
Cytarabine	7	0.84	288	0.48	0.6	.43
		(0.45-1.34)		(0.25-1.19)
Daunorubicin	9	0.10	387	0.09	0.9	.94
		(0.07-0.11)		(0.06-0.15)
Idarubicin	4	0.021	145	0.035	1.7	.29
		(0.014-0.046)		(0.022-0.086)
Doxorubicin	7	0.26	193	0.27	1.0	.68
		(0.22-0.28)		(0.12-0.37)
Mitoxantrone	6	0.037	197	0.045	1.2	.85
		(0.019-0.166)		(0.015-0.102)
6-Thioguanine	7	5.88	297	5.92	1.0	.78
		(4.12-8.03)		(3.83-8.60)
6-Mercaptopurine	4	158.8	278	97.9	0.6	.53
		(<15.0-302.6)		(50.6-240.0)
Prednisolone	9	0.12	352	0.46	3.8	.12
		(0.04-2.37)		(0.19-19.7)
Dexamethasone	4	0.07	239	0.06	0.9	.77
		(0.05-1.59)		(0.01-0.47)
Vincristine	8	0.53	371	0.68	1.3	.53
		(0.15-1.79)		(0.24-2.50)
L-Asparaginase	9	0.35	352	0.08	0.2	.40
		(0.03-1.37)		(0.01-1.04)
Methotrexate	10	0.34	88	0.42	1.2	.69
(TSI₅₀short)		(0.17-1.85)		(0.16-1.43)
Methotrexate	11	0.05	94	0.09	1.8	.16
(TSI₅₀cont)		(0.02-0.13)		(0.04-0.19)

Drug	DS ALL		Non-DS BCP-ALL		RR	P
Drug	N	Median (P25-P75)	N	Median (P25-P75)	RR	P
Cytarabine	7	0.84	288	0.48	0.6	.43
		(0.45-1.34)		(0.25-1.19)
Daunorubicin	9	0.10	387	0.09	0.9	.94
		(0.07-0.11)		(0.06-0.15)
Idarubicin	4	0.021	145	0.035	1.7	.29
		(0.014-0.046)		(0.022-0.086)
Doxorubicin	7	0.26	193	0.27	1.0	.68
		(0.22-0.28)		(0.12-0.37)
Mitoxantrone	6	0.037	197	0.045	1.2	.85
		(0.019-0.166)		(0.015-0.102)
6-Thioguanine	7	5.88	297	5.92	1.0	.78
		(4.12-8.03)		(3.83-8.60)
6-Mercaptopurine	4	158.8	278	97.9	0.6	.53
		(<15.0-302.6)		(50.6-240.0)
Prednisolone	9	0.12	352	0.46	3.8	.12
		(0.04-2.37)		(0.19-19.7)
Dexamethasone	4	0.07	239	0.06	0.9	.77
		(0.05-1.59)		(0.01-0.47)
Vincristine	8	0.53	371	0.68	1.3	.53
		(0.15-1.79)		(0.24-2.50)
L-Asparaginase	9	0.35	352	0.08	0.2	.40
		(0.03-1.37)		(0.01-1.04)
Methotrexate	10	0.34	88	0.42	1.2	.69
(TSI₅₀short)		(0.17-1.85)		(0.16-1.43)
Methotrexate	11	0.05	94	0.09	1.8	.16
(TSI₅₀cont)		(0.02-0.13)		(0.04-0.19)

LC₅₀ values are given in μg/mL. For MTX, the TSI₅₀ values (μM) are given after short-term (TSI₅₀ short) or long-term (TSI₅₀ cont) exposure.

RR, the median LC₅₀ value (for MTX, TSI₅₀) for non-DS ALL divided by the median LC₅₀ value (for MTX, TSI₅₀) for DS ALL.

P value derived from 2-tailed Mann-Whitney Utest.

L-asparaginase is given in IU/mL, not in μg/mL.

N indicates number of samples tested; P25-P75, 25^th and 75^th percentiles.