Estimation of conditioning effect in each diagnostic group on each end point
| End point . | AML (n = 172) (95% CI; P) . | CML (n = 316) (95% CI; P) . |
|---|---|---|
| Cataract | 11 events | 66 events |
| BUCY vs CY-TBI | 1.05 (0.32-3.44; .94) | 2.67 (1.56-4.57; .0003) |
| Multivariable model | ||
| BUCY vs CY-TBI | 1.05 (0.31-3.57; .94) | 2.32 (1.32-4.07; .0035) |
| Acute GVHD | 1.05 (0.30-3.69; .94) | 1.37 (0.76-2.48; .30) |
| Chronic GVHD | 0.27 (0.03-2.39; .24) | 2.99 (1.64-5.44; .0003) |
| Age | 1.02 (0.96-1.08; .51) | 0.998 (0.975-1.023; .89) |
| Pulmonary complications | 9 events | 46 events |
| BUCY vs CY-TBI | 0.75 (0.20-2.80; .67) | 0.80 (0.44-1.48; .48) |
| Multivariable model | ||
| BUCY vs CY-TBI | 0.55 (0.14-2.11; .38) | 0.70 (0.36-1.33; .27) |
| Acute GVHD | 4.46 (0.85-23.5; .078) | 1.32 (0.68-2.56; .41) |
| Chronic GVHD | 1.60 (0.30-8.48; .58) | 2.62 (1.31-5.27; .0067) |
| Age | 0.995 (0.941-1.052; .86) | 0.988 (0.958-1.019; .45) |
| Avascular osteonecrosis | 10 events | 19 events |
| BUCY vs CY-TBI | 1.04 (0.30-3.62; .95) | 3.09 (1.11-8.57; .0307) |
| Multivariable model | ||
| BUCY vs CY-TBI | 1.04 (0.30-3.64; .95) | 2.52 (0.86-7.43; .094) |
| Acute GVHD | 0.79 (0.21-3.03; .73) | 1.33 (0.44-4.01; .61) |
| Chronic GVHD | 3.18 (0.60-16.9; .17) | 7.01 (1.85-26.5; .0041) |
| Age | 0.972 (0.917-1.030; .34) | 0.925 (0.880-0.972; .0021) |
| Hair loss | 58 events/86 | 66 events/98 |
| BUCY vs CY-TBI | 0.30 (0.12-0.80; .016) | 0.61 (0.26-1.43; .25) |
| Multivariable model | ||
| BUCY vs CY-TBI | 0.19 (0.06-0.58; .0035) | 0.79 (0.32-1.95; .61) |
| Acute GVHD | 2.53 (0.81-7.91; .11) | 1.08 (0.43-2.70; .87) |
| Chronic GVHD | 2.74 (0.50-15.0; .25) | 3.26 (1.11-9.59; .032) |
| Age | 1.046 (1.001-1.094; .046) | 1.027 (0.972-1.077; .37) |
| End point . | AML (n = 172) (95% CI; P) . | CML (n = 316) (95% CI; P) . |
|---|---|---|
| Cataract | 11 events | 66 events |
| BUCY vs CY-TBI | 1.05 (0.32-3.44; .94) | 2.67 (1.56-4.57; .0003) |
| Multivariable model | ||
| BUCY vs CY-TBI | 1.05 (0.31-3.57; .94) | 2.32 (1.32-4.07; .0035) |
| Acute GVHD | 1.05 (0.30-3.69; .94) | 1.37 (0.76-2.48; .30) |
| Chronic GVHD | 0.27 (0.03-2.39; .24) | 2.99 (1.64-5.44; .0003) |
| Age | 1.02 (0.96-1.08; .51) | 0.998 (0.975-1.023; .89) |
| Pulmonary complications | 9 events | 46 events |
| BUCY vs CY-TBI | 0.75 (0.20-2.80; .67) | 0.80 (0.44-1.48; .48) |
| Multivariable model | ||
| BUCY vs CY-TBI | 0.55 (0.14-2.11; .38) | 0.70 (0.36-1.33; .27) |
| Acute GVHD | 4.46 (0.85-23.5; .078) | 1.32 (0.68-2.56; .41) |
| Chronic GVHD | 1.60 (0.30-8.48; .58) | 2.62 (1.31-5.27; .0067) |
| Age | 0.995 (0.941-1.052; .86) | 0.988 (0.958-1.019; .45) |
| Avascular osteonecrosis | 10 events | 19 events |
| BUCY vs CY-TBI | 1.04 (0.30-3.62; .95) | 3.09 (1.11-8.57; .0307) |
| Multivariable model | ||
| BUCY vs CY-TBI | 1.04 (0.30-3.64; .95) | 2.52 (0.86-7.43; .094) |
| Acute GVHD | 0.79 (0.21-3.03; .73) | 1.33 (0.44-4.01; .61) |
| Chronic GVHD | 3.18 (0.60-16.9; .17) | 7.01 (1.85-26.5; .0041) |
| Age | 0.972 (0.917-1.030; .34) | 0.925 (0.880-0.972; .0021) |
| Hair loss | 58 events/86 | 66 events/98 |
| BUCY vs CY-TBI | 0.30 (0.12-0.80; .016) | 0.61 (0.26-1.43; .25) |
| Multivariable model | ||
| BUCY vs CY-TBI | 0.19 (0.06-0.58; .0035) | 0.79 (0.32-1.95; .61) |
| Acute GVHD | 2.53 (0.81-7.91; .11) | 1.08 (0.43-2.70; .87) |
| Chronic GVHD | 2.74 (0.50-15.0; .25) | 3.26 (1.11-9.59; .032) |
| Age | 1.046 (1.001-1.094; .046) | 1.027 (0.972-1.077; .37) |
Results show estimation of conditioning effect in each diagnostic group on each end point either unadjusted or adjusted on baseline covariates, stratified on trial, using Cox models with estimated HR (for cataracts, pulmonary complications, and avascular osteonecrosis) or logistic models with estimated OR (for hair loss). SignificantP values are in bold.