Quantitative imbalance in the proportions of circulating MDC and PDC subsets in patients with acute myeloid leukemia
| Group . | n . | % MDCs . | % PDCs . |
|---|---|---|---|
| Healthy donors | 15 | 0.26 ± 0.23 | 0.24 ± 0.18 |
| (0.01-0.8) | (0.01-0.7) | ||
| Group I | 11 | 0.37 ± 0.21 | 0.21 ± 0.24 |
| (1 M2, 2 M4, 7 M5, 1 M7) | (0.01-0.78) | (0.04-0.62) | |
| Group II | |||
| MDC expansion | 9 | 16.76 ± 14.03 | 0.39 ± 0.23 |
| (1 M2, 1 M4, 6 M5, 1 M6) | (1.36-41) | (0.22-0.82) | |
| PDC expansion | 4 | 0.37 ± 0.39 | 7.28 ± 6.84 |
| (1 M1, 1 M3, 2 M5) | (0.04-0.78) | (1-14) | |
| MDC and PDC expansion | 9 | 10.86 ± 12.36 | 4.25 ± 3.78 |
| (2 M3, 3 M4, 3 M5, 1 M7) | (1.02-37.1) | (1.14-13.04) | |
| Group III | 4 | 0 | 0 |
| (2 M1, 2 M4) |
| Group . | n . | % MDCs . | % PDCs . |
|---|---|---|---|
| Healthy donors | 15 | 0.26 ± 0.23 | 0.24 ± 0.18 |
| (0.01-0.8) | (0.01-0.7) | ||
| Group I | 11 | 0.37 ± 0.21 | 0.21 ± 0.24 |
| (1 M2, 2 M4, 7 M5, 1 M7) | (0.01-0.78) | (0.04-0.62) | |
| Group II | |||
| MDC expansion | 9 | 16.76 ± 14.03 | 0.39 ± 0.23 |
| (1 M2, 1 M4, 6 M5, 1 M6) | (1.36-41) | (0.22-0.82) | |
| PDC expansion | 4 | 0.37 ± 0.39 | 7.28 ± 6.84 |
| (1 M1, 1 M3, 2 M5) | (0.04-0.78) | (1-14) | |
| MDC and PDC expansion | 9 | 10.86 ± 12.36 | 4.25 ± 3.78 |
| (2 M3, 3 M4, 3 M5, 1 M7) | (1.02-37.1) | (1.14-13.04) | |
| Group III | 4 | 0 | 0 |
| (2 M1, 2 M4) |
Thirty-seven leukemic samples were analyzed for distribution of circulating MDC and PDC subsets. Eleven patients (group I) displayed a quantitative profile similar to that of healthy donors; 22 patients (group II) showed an expansion of MDCs, PDCs, or both subsets; 4 patients (group III) had no detectable DC subsets. Data are presented as mean ± SD (range).