Table 2. Desensitization of CXCR3 by... | American Society of Hematology

Table 2.

Desensitization of CXCR3 by CD26/DPP IV–truncated chemokines

First stimulus^*	Second stimulus	Desensitization^†(%)
10 nM IP-10(3-77)	1 nM IP-10(1-77)	37
	0.3 nM IP-10(1-77)	39
	50 nM Mig(1-103)	34
	0.3 nM I-TAC(1-73)	29
3 nM I-TAC(3-73)	0.3 nM IP-10(1-77)	31
	0.3 nM I-TAC(1-73)	32

First stimulus^*	Second stimulus	Desensitization^†(%)
10 nM IP-10(3-77)	1 nM IP-10(1-77)	37
	0.3 nM IP-10(1-77)	39
	50 nM Mig(1-103)	34
	0.3 nM I-TAC(1-73)	29
3 nM I-TAC(3-73)	0.3 nM IP-10(1-77)	31
	0.3 nM I-TAC(1-73)	32

The first stimulus did not induce an increase of the intracellular calcium concentration.

†

Compared to CXCR3-transfected CHO cells that were treated with calcium buffer as a first stimulus (average percent desensitization of 2-4 independent experiments).

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