HLA phenotypes of patients with bone marrow failure and PNH
| Comparison . | HLA-A . | HLA-B . | HLA-C . | HLA-DR . | HLA-DQ . |
|---|---|---|---|---|---|
| Hemolytic PNH vs controls† | NS | NS | NS | DR2; 54% vs 28% z = 4.1 N = 48 | NS |
| Expanded PNH clone present (PNH/AA, PNH/MDS, PNH) vs controls | NS | NS | NS | DR2; 58% vs 28% z = 6.4 N = 89 | NS |
| PNH/AA syndrome vs controls | NS | NS | NS | DR2; 56% vs 28% z = 4.5 N = 48 | NS |
| PNH/MDS vs controls | NS | B7; 48% vs 21% z = 3.5 N = 27 | NS | DR2; 74% vs 28% z = 5.3 N = 29 | NS |
| Comparison . | HLA-A . | HLA-B . | HLA-C . | HLA-DR . | HLA-DQ . |
|---|---|---|---|---|---|
| Hemolytic PNH vs controls† | NS | NS | NS | DR2; 54% vs 28% z = 4.1 N = 48 | NS |
| Expanded PNH clone present (PNH/AA, PNH/MDS, PNH) vs controls | NS | NS | NS | DR2; 58% vs 28% z = 6.4 N = 89 | NS |
| PNH/AA syndrome vs controls | NS | NS | NS | DR2; 56% vs 28% z = 4.5 N = 48 | NS |
| PNH/MDS vs controls | NS | B7; 48% vs 21% z = 3.5 N = 27 | NS | DR2; 74% vs 28% z = 5.3 N = 29 | NS |
NS indicates not significant.
No statistical differences in HLA phenotype were detected between the patients with florid hemolytic PNH and all other patients in whom PNH clone was detected (64% vs 54%, z = 0.88).
All patients with current florid hemolytic PNH irrespective of the original diagnosis.