Diagnostic criteria and definitions
| Main clinical diagnosis . | Clinical subgroups based on past medical history . | N . |
|---|---|---|
| AA | AA without PNH clone | 212 |
| AA with PNH clone | 48 | |
| MDS (including MDS that evolved from AA) | MDS without PNH clone | 110 |
| MDS with PNH clone | 29 | |
| Patients with an expanded PNH clone (includes all categories of bone marrow failure syndrome) at any time during the course of their disease | Primary hemolytic PNH | 16 |
| AA/PNH syndrome, current or past diagnosis of AA with positive PNH test | 48 | |
| MDS/PNH syndrome underlying diagnosis of MDS and positive PNH test | 29 | |
| Hemolytic form of PNH | Primary hemolytic PNH, no evidence of bone marrow failure | 16 |
| Hemolytic PNH evolved from initial AA | 19 | |
| Hemolytic PNH in context of MDS (dysplasia, karyotypic abnormalities) | 11 |
| Main clinical diagnosis . | Clinical subgroups based on past medical history . | N . |
|---|---|---|
| AA | AA without PNH clone | 212 |
| AA with PNH clone | 48 | |
| MDS (including MDS that evolved from AA) | MDS without PNH clone | 110 |
| MDS with PNH clone | 29 | |
| Patients with an expanded PNH clone (includes all categories of bone marrow failure syndrome) at any time during the course of their disease | Primary hemolytic PNH | 16 |
| AA/PNH syndrome, current or past diagnosis of AA with positive PNH test | 48 | |
| MDS/PNH syndrome underlying diagnosis of MDS and positive PNH test | 29 | |
| Hemolytic form of PNH | Primary hemolytic PNH, no evidence of bone marrow failure | 16 |
| Hemolytic PNH evolved from initial AA | 19 | |
| Hemolytic PNH in context of MDS (dysplasia, karyotypic abnormalities) | 11 |
HLA-Cw and class II typing was not available for all patients.