Relationships between platelet membrane glycoprotein polymorphisms and collagen-induced thrombus formation
| Shear rate (s−1) . | n . | Platelet deposition (× 10−7/cm2) . | |
|---|---|---|---|
| 650 . | 2600 . | ||
| GPIb Kozak | |||
| T/T | 32 | 0.85 ± 0.42 | 3.89 ± 1.45 |
| T/C | 8 | 1.38 ± 0.60 | 5.20 ± 2.58 |
| p | — | 0.01 | NS |
| GPIb VNTR | |||
| B/B | 1 | 1.14 | 3.70 |
| B/C | 7 | 1.00 ± 0.34 | 4.53 ± 1.42 |
| C/C | 24 | 0.96 ± 0.51 | 4.01 ± 1.90 |
| C/D | 8 | 0.87 ± 0.64 | 4.30 ± 1.91 |
| p | — | NS | NS |
| GPIa 807 | |||
| C/C | 17 | 0.94 ± 0.45 | 3.47 ± 1.35 |
| C/T | 17 | 0.92 ± 0.37 | 4.22 ± 1.46 |
| T/T | 6 | 1.07 ± 0.91 | 5.88 ± 2.61 |
| p | — | NS | 0.03 |
| GPIIb/IIIa | |||
| P1A1/A1 | 21 | 0.97 ± 0.42 | 4.08 ± 1.77 |
| P1A1/A1 | 19 | 0.94 ± 0.58 | 4.23 ± 1.82 |
| p | — | NS | NS |
| Shear rate (s−1) . | n . | Platelet deposition (× 10−7/cm2) . | |
|---|---|---|---|
| 650 . | 2600 . | ||
| GPIb Kozak | |||
| T/T | 32 | 0.85 ± 0.42 | 3.89 ± 1.45 |
| T/C | 8 | 1.38 ± 0.60 | 5.20 ± 2.58 |
| p | — | 0.01 | NS |
| GPIb VNTR | |||
| B/B | 1 | 1.14 | 3.70 |
| B/C | 7 | 1.00 ± 0.34 | 4.53 ± 1.42 |
| C/C | 24 | 0.96 ± 0.51 | 4.01 ± 1.90 |
| C/D | 8 | 0.87 ± 0.64 | 4.30 ± 1.91 |
| p | — | NS | NS |
| GPIa 807 | |||
| C/C | 17 | 0.94 ± 0.45 | 3.47 ± 1.35 |
| C/T | 17 | 0.92 ± 0.37 | 4.22 ± 1.46 |
| T/T | 6 | 1.07 ± 0.91 | 5.88 ± 2.61 |
| p | — | NS | 0.03 |
| GPIIb/IIIa | |||
| P1A1/A1 | 21 | 0.97 ± 0.42 | 4.08 ± 1.77 |
| P1A1/A1 | 19 | 0.94 ± 0.58 | 4.23 ± 1.82 |
| p | — | NS | NS |
The relationship between the 4 polymorphisms and platelet deposition was analyzed by using a stepwise multiple linear regression analysis. This relationship was determined by adjusting other important blood parameters susceptible to influence platelet thrombus formation (ie, individual platelet count, white blood cell count, hematocrit, fibrinogen, and von Willebrand factor plasma levels). GP, glycoprotein; VNTR, variable number of tandem repeat; NS = not significant. Mean ± SD.