Effect of prostratin on multiple gene expression as determined by gene array
| Gene name . | Fold increase . | Gene name . | Fold decrease . |
|---|---|---|---|
| IL-1β | 35.53 | PARC | 7.34 |
| CKRL-1 | 30.38 | TIMP-4 | 5.27 |
| Osteopontin | 27.54 | erbB1 | 4.92 |
| IL-8 | 24.99 | CD6 | 4.75 |
| MMP-9 | 15.25 | EMMPRIN | 4.57 |
| OSM Rβ | 9.98 | β-NGF | 4.06 |
| MPIF-1 | 8.90 | Tpo | 3.24 |
| IFN-α/β Rα | 8.06 | IGF binding protein 1 | 3.21 |
| Integrin-α5 | 6.59 | IGF binding protein 4 | 3.06 |
| Ephrin-A1 | 6.42 | Inhibin (α subunit) | 3.01 |
| LIGHT | 5.42 | BMP-8 | 2.98 |
| TACE | 5.32 | CD64 | 2.79 |
| Activin RIIA | 4.56 | Endothelin-2 | 2.76 |
| TIMP-1 | 4.52 | CD34 | 2.66 |
| SARP-1 | 4.18 | RANTES | 2.58 |
| MIP-1α | 4.14 | CCR-5 | 2.56 |
| PBEF | 3.87 | IL-12 p40 | 2.53 |
| Integrin-β2 | 3.82 | FGF R2 | 2.50 |
| Bob | 3.62 | NT-4 | 2.49 |
| GAPDH | 3.14 | IGF-I R | 2.46 |
| Integrin-αL | 3.11 | MIP-1β | 2.42 |
| MCP-1 | 3.09 | CXCR-4 | 2.40 |
| PDGF-A chain | 2.95 | CD4 | 2.39 |
| FGF R3 | 2.85 | CD38 | 2.36 |
| IFN-α/β Rβ | 2.80 | ICAM-3 | 2.36 |
| MMP-7 | 2.77 | PDGF Rα | 2.27 |
| GRO-γ | 2.75 | CXCR-2 | 2.22 |
| IL-1α | 2.74 | HCC-4 | 2.19 |
| PIN | 2.72 | CCR-6 | 2.16 |
| HLA-A 0201 heavy chain | 2.70 | N-Cadherin | 2.15 |
| Integrin-α3 | 2.65 | FGF-11 | 2.12 |
| Integrin-α2 | 2.64 | CD27L | 2.12 |
| Urokinase R | 2.64 | GFRα2 | 2.09 |
| Oncostatin M | 2.62 | MMP-15 | 2.03 |
| IL-3 Rα | 2.61 | ICAM-2 | 1.96 |
| Gene name . | Fold increase . | Gene name . | Fold decrease . |
|---|---|---|---|
| IL-1β | 35.53 | PARC | 7.34 |
| CKRL-1 | 30.38 | TIMP-4 | 5.27 |
| Osteopontin | 27.54 | erbB1 | 4.92 |
| IL-8 | 24.99 | CD6 | 4.75 |
| MMP-9 | 15.25 | EMMPRIN | 4.57 |
| OSM Rβ | 9.98 | β-NGF | 4.06 |
| MPIF-1 | 8.90 | Tpo | 3.24 |
| IFN-α/β Rα | 8.06 | IGF binding protein 1 | 3.21 |
| Integrin-α5 | 6.59 | IGF binding protein 4 | 3.06 |
| Ephrin-A1 | 6.42 | Inhibin (α subunit) | 3.01 |
| LIGHT | 5.42 | BMP-8 | 2.98 |
| TACE | 5.32 | CD64 | 2.79 |
| Activin RIIA | 4.56 | Endothelin-2 | 2.76 |
| TIMP-1 | 4.52 | CD34 | 2.66 |
| SARP-1 | 4.18 | RANTES | 2.58 |
| MIP-1α | 4.14 | CCR-5 | 2.56 |
| PBEF | 3.87 | IL-12 p40 | 2.53 |
| Integrin-β2 | 3.82 | FGF R2 | 2.50 |
| Bob | 3.62 | NT-4 | 2.49 |
| GAPDH | 3.14 | IGF-I R | 2.46 |
| Integrin-αL | 3.11 | MIP-1β | 2.42 |
| MCP-1 | 3.09 | CXCR-4 | 2.40 |
| PDGF-A chain | 2.95 | CD4 | 2.39 |
| FGF R3 | 2.85 | CD38 | 2.36 |
| IFN-α/β Rβ | 2.80 | ICAM-3 | 2.36 |
| MMP-7 | 2.77 | PDGF Rα | 2.27 |
| GRO-γ | 2.75 | CXCR-2 | 2.22 |
| IL-1α | 2.74 | HCC-4 | 2.19 |
| PIN | 2.72 | CCR-6 | 2.16 |
| HLA-A 0201 heavy chain | 2.70 | N-Cadherin | 2.15 |
| Integrin-α3 | 2.65 | FGF-11 | 2.12 |
| Integrin-α2 | 2.64 | CD27L | 2.12 |
| Urokinase R | 2.64 | GFRα2 | 2.09 |
| Oncostatin M | 2.62 | MMP-15 | 2.03 |
| IL-3 Rα | 2.61 | ICAM-2 | 1.96 |
The mRNA expression levels increased in THP-1 cells after prostratin treatment relative to untreated cells are indicated as fold differences on the left side; mRNA expression levels decreased by fold after prostratin treatment are listed on the right side. The table lists the first 35 genes in each category.