Cox univariate and bivariate analyses evaluating the effect of amino acid substitutions at different positions on transplant-related mortality
| Variable . | Univariate analysis . | Bivariate analysis . | |||
|---|---|---|---|---|---|
| Type . | HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Number of substitutions | Ordinal | 1.06 (1.01-1.10) | .02 | — | — |
| Position 9 | Binary | 1.66 (0.87-3.18) | .07 | 1.03 (0.45-2.35) | .94 |
| Position 24 | Binary | 1.80 (0.91-3.57) | .09 | 1.27 (0.59-2.74) | .54 |
| Position 66 | Binary | 1.14 (0.54-2.41) | .73 | 0.83 (0.38-1.80) | .63 |
| Position 77 | Binary | 1.32 (0.63-2.80) | .46 | 0.53 (0.19-1.46) | .22 |
| Position 80 | Binary | 1.32 (0.63-2.80) | .46 | 0.53 (0.19-1.46) | .22 |
| Position 95 | Binary | 1.13 (0.52-2.49) | .76 | 0.61 (0.24-1.45) | .30 |
| Position 97 | Binary | 1.67 (0.86-3.23) | .13 | 1.08 (0.47-2.44) | .86 |
| Position 99 | Binary | 1.51 (0.73-3.13) | .26 | 0.99 (0.44-2.26) | .98 |
| Position 114 | Binary | 2.30 (1.19-4.46) | .01 | 1.71 (0.69-4.27) | .25 |
| Position 116 | Binary | 2.75 (1.44-5.23) | .002 | 2.47 (1.06-5.71) | .03 |
| Position 152 | Binary | 1.81 (0.90-3.65) | .10 | 1.20 (0.52-2.78) | .66 |
| Position 156 | Binary | 1.83 (0.97-3.47) | .07 | 1.09 (0.40-2.98) | .86 |
| Variable . | Univariate analysis . | Bivariate analysis . | |||
|---|---|---|---|---|---|
| Type . | HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Number of substitutions | Ordinal | 1.06 (1.01-1.10) | .02 | — | — |
| Position 9 | Binary | 1.66 (0.87-3.18) | .07 | 1.03 (0.45-2.35) | .94 |
| Position 24 | Binary | 1.80 (0.91-3.57) | .09 | 1.27 (0.59-2.74) | .54 |
| Position 66 | Binary | 1.14 (0.54-2.41) | .73 | 0.83 (0.38-1.80) | .63 |
| Position 77 | Binary | 1.32 (0.63-2.80) | .46 | 0.53 (0.19-1.46) | .22 |
| Position 80 | Binary | 1.32 (0.63-2.80) | .46 | 0.53 (0.19-1.46) | .22 |
| Position 95 | Binary | 1.13 (0.52-2.49) | .76 | 0.61 (0.24-1.45) | .30 |
| Position 97 | Binary | 1.67 (0.86-3.23) | .13 | 1.08 (0.47-2.44) | .86 |
| Position 99 | Binary | 1.51 (0.73-3.13) | .26 | 0.99 (0.44-2.26) | .98 |
| Position 114 | Binary | 2.30 (1.19-4.46) | .01 | 1.71 (0.69-4.27) | .25 |
| Position 116 | Binary | 2.75 (1.44-5.23) | .002 | 2.47 (1.06-5.71) | .03 |
| Position 152 | Binary | 1.81 (0.90-3.65) | .10 | 1.20 (0.52-2.78) | .66 |
| Position 156 | Binary | 1.83 (0.97-3.47) | .07 | 1.09 (0.40-2.98) | .86 |
Bivariate analysis values were determined after adjusting for the total number of other substitutions.