Advantages and disadvantages of TCD
| Advantages . | Disadvantages . |
|---|---|
| Low incidence of acute and chronic GVHD | Higher incidence of graft failure |
| Reduced or no requirement for posttransplantation immune suppression as GVHD prophylaxis | Loss of GVL activity (higher incidence of disease relapse, especially with CML) Delayed immune reconstitution |
| Decreased pulmonary and hepatic toxicity early after BMT | Increased risk for posttransplantation EBV-LPDs |
| Decreased early transplant-related mortality | Higher incidence of CMV reactivation |
| ? Shorter time to engraftment | Overall survival not improved compared to non-TCD BMT |
| ? Decreased cost |
| Advantages . | Disadvantages . |
|---|---|
| Low incidence of acute and chronic GVHD | Higher incidence of graft failure |
| Reduced or no requirement for posttransplantation immune suppression as GVHD prophylaxis | Loss of GVL activity (higher incidence of disease relapse, especially with CML) Delayed immune reconstitution |
| Decreased pulmonary and hepatic toxicity early after BMT | Increased risk for posttransplantation EBV-LPDs |
| Decreased early transplant-related mortality | Higher incidence of CMV reactivation |
| ? Shorter time to engraftment | Overall survival not improved compared to non-TCD BMT |
| ? Decreased cost |