Comparative quantitative trait linkage analysis
. | Linked locus . | Trait . | |||
---|---|---|---|---|---|
Young animals (< 3 mo) . | Old animals (> 18 mo) . | ||||
eHPCs/femur . | HSCs/femur . | eHPCs/femur . | HSCs/femur . | ||
Chr1 | (D1Mit282, 38 cM) | B++ | B+++ | ||
(D1Mit150, 100 cM) | D+ | ||||
Chr2 | (D2Mit423, 72 cM) | B++ | B+++ | ||
Chr3 | (D3Mit6, 24 cM) | D++ | |||
Chr5 | (D5Mit352, 20 cM) | D++ | |||
Chr7 | (D7Mit114, 8 cM) | D+ | |||
(D7Mit145, 25 cM) | D+ | ||||
(Hbb, 50 cM) | D++ | D+++ | |||
Chr14 | (D14Mit45, 13 cM) | D++ | |||
Chr15 | (D15Mit42, 59 cM) | B+ | |||
Chr18 | (D18Mit53, 27 cM) | D+ | D++ | D++ | |
ChrX | (DXMit38, 51 cM) | B++ |
. | Linked locus . | Trait . | |||
---|---|---|---|---|---|
Young animals (< 3 mo) . | Old animals (> 18 mo) . | ||||
eHPCs/femur . | HSCs/femur . | eHPCs/femur . | HSCs/femur . | ||
Chr1 | (D1Mit282, 38 cM) | B++ | B+++ | ||
(D1Mit150, 100 cM) | D+ | ||||
Chr2 | (D2Mit423, 72 cM) | B++ | B+++ | ||
Chr3 | (D3Mit6, 24 cM) | D++ | |||
Chr5 | (D5Mit352, 20 cM) | D++ | |||
Chr7 | (D7Mit114, 8 cM) | D+ | |||
(D7Mit145, 25 cM) | D+ | ||||
(Hbb, 50 cM) | D++ | D+++ | |||
Chr14 | (D14Mit45, 13 cM) | D++ | |||
Chr15 | (D15Mit42, 59 cM) | B+ | |||
Chr18 | (D18Mit53, 27 cM) | D+ | D++ | D++ | |
ChrX | (DXMit38, 51 cM) | B++ |
In the first column all loci that were mapped with an at least suggestive linkage value are shown with their peak centimorgan (cM) position. The type of capital letter indicates which segment (either DBA/2 [D] or C57BL/6 [B] derived) is responsible for a higher trait value. The linkage analysis for the hematopoietic traits was based on trait values of all then-available 26 strains, and the linkage analysis for the hematopoietic traits in old animals included trait values of 20 strains. The BXD marker database contains 319 marker loci with a complete strain distribution pattern, providing on average a 3.75-cM mapping resolution. On the basis of a 5000-permutation test, for all linked loci the suggestive, significant, and highly significant likelihood ratio statistics (LRS) values were individually calculated: +, suggestive; ++, higher than suggestive and up to significant; and +++, above significant.
eHPC, early hematopoietic progenitor cell; HSC, hematopoietic stem cell.