Prognostic features reported to be associated with mortality in patients who required mechanical ventilation after HSCT
| Author, year . | No. of features assessed . | Identified poor prognostic feature . | Prevalence of feature (%) . | Mortality rate in presence of feature (%)5-150 . |
|---|---|---|---|---|
| Crawford et al, 19882 | 14 | Age ≥ 21 years | 66 | 905-151 |
| Denardo et al, 198921 | NR | >4 days of ventilation | 52 | 1005-151 |
| Faber-Langendoen et al, 19938 | 6 | Age ≥ 40 years | 27 | 1005-151 |
| Intubated before 90 days | 65 | 955-151 | ||
| Rubenfeld and Crawford, 19963 | 35-152 | 4 hrs vasopressors5-153 | 48 | 1005-151 |
| Lung injury5-155 | 64 | 985-151 | ||
| Hepatic & renal injury5-154 | 45 | 985-151 | ||
| LI combined with either HR or V5-159 | 46 | 1005-151 | ||
| Price et al, 1998235-160 | 20 | BMT rather than PBSCT | 46 | 955-151 |
| RR > 25 bpm | 63 | 935-151 | ||
| Shorr et al, 199933 | NR | Apache II score ≥ 29 | NR | 100 |
| Huaringa et al, 200027 | 9 | HSCT for diagnosis other than breast cancer | 90 | 875-151 |
| Intubated after 30 days | 48 | 975-151 |
| Author, year . | No. of features assessed . | Identified poor prognostic feature . | Prevalence of feature (%) . | Mortality rate in presence of feature (%)5-150 . |
|---|---|---|---|---|
| Crawford et al, 19882 | 14 | Age ≥ 21 years | 66 | 905-151 |
| Denardo et al, 198921 | NR | >4 days of ventilation | 52 | 1005-151 |
| Faber-Langendoen et al, 19938 | 6 | Age ≥ 40 years | 27 | 1005-151 |
| Intubated before 90 days | 65 | 955-151 | ||
| Rubenfeld and Crawford, 19963 | 35-152 | 4 hrs vasopressors5-153 | 48 | 1005-151 |
| Lung injury5-155 | 64 | 985-151 | ||
| Hepatic & renal injury5-154 | 45 | 985-151 | ||
| LI combined with either HR or V5-159 | 46 | 1005-151 | ||
| Price et al, 1998235-160 | 20 | BMT rather than PBSCT | 46 | 955-151 |
| RR > 25 bpm | 63 | 935-151 | ||
| Shorr et al, 199933 | NR | Apache II score ≥ 29 | NR | 100 |
| Huaringa et al, 200027 | 9 | HSCT for diagnosis other than breast cancer | 90 | 875-151 |
| Intubated after 30 days | 48 | 975-151 |
No. tested indicates number of prognostic features assessed; NR, not reported; BMT, bone marrow transplant; PBSCT, peripheral blood stem cell transplantation; V, vasopressors; LI, lung injury; HR, hepatic and renal injury.
This is the positive predictive value of the feature.
P < .05.
Authors specified that they intended to evaluate both the individual predictors listed, as well as combinations of these predictors.
Dopamine > 5 μg/kg/min or norepinephrine, epinephrine, or phenylephrine at any dose at any time after admission.
Lung injury: Fraction of inspired oxygen > 60% or positive end expiratory pressure (PEEP) > 5 cm H20 after the first 24 hours of admission.
Simultaneous elevation of serum bilirubin > 68 μmol/L (4 mg/dL) and serum creatinine > 177 μmol/L (2 mg/dL) within the first 3 days of admission.
Defined as the presence of lung injury and one or more of the other characteristics (hepatic and renal injury or 4 hours of vasopressors).
Original analysis by Price et al. performed on a subset of validation cohort.