Study design and reported short- and long-term survival statistics for 15 prior studies and validation cohort: patients requiring mechanical ventilation after hematopoietic stem cell transplantation
| Author, year . | N . | Study design (no. of centers) . | Endpoint used to demarcate short-term survival . | Short-term survival N (%) . | Six-month survival N (%)4-150 . | Median survival of short-term survivors . |
|---|---|---|---|---|---|---|
| Crawford et al, 19882 | 232 | Ret coh (1) | One month after MV discontinued | 31 (13) | 12 (39) | NR |
| Torrecilla et al, 19884 | 16 | Ret coh (1) | Hospital discharge | 1 (6) | NR | NR |
| Denardo et al, 198921 | 44 | Ret coh (1) | Hospital discharge | 1 (2) | NR | NR |
| Afessa et al, 199229 | 27 | Ret coh (1) | Not specified | 2 (7) | NR | NR |
| Crawford and Peterson, 19921 | 348 | Ret coh (1) | Hospital discharge | 15 (4) | 10 (66) | NR |
| Paz et al, 199330 | 28 | Ret coh (1) | ICU discharge | 1 (4) | NR | NR |
| Faber-Langendoen et al, 19938 | 191 | Ret coh (1) | One month after MV discontinued | 16 (8) | 6 (38) | NR |
| Rubenfeld and Crawford, 19963 | 865 | NCC (1) | One month after hospital discharge | 53 (6) | 35 (66) | 634 days |
| Epner et al, 199632 | 71 | Ret coh (1) | Hospital discharge | 7 (10) | NR | NR |
| Hollmig et al, 19975 | 10 | Ret coh (1) | ICU discharge | 4 (40) | NR | NR |
| Jackson et al, 199831 | 92 | Ret coh (1) | Discharge from hospital | 16 (17) | 14 (88) | NR |
| Price et al,4-151199823 | 48 | Pro coh (1) | Discharge from hospital | 9 (19) | NR | NR |
| Ewig et al, 199828 | 50 | Ret coh (1) | ICU discharge | 2 (4-5)‡ | NR | NR |
| Shorr et al, 199933 | 17 | Pro coh (1) | Hospital discharge | 3 (18) | NR | NR |
| Huaringa et al, 200027 | 60 | Ret coh (1) | ICU discharge | 11 (18) | 3 (27) | NR |
| Validation cohort | 226 | Pro coh (5) | Discharge from hospital | 32 (14) | 20 (63) | 451 days |
| One month after hospital discharge | 30 (13) | 20 (67) |
| Author, year . | N . | Study design (no. of centers) . | Endpoint used to demarcate short-term survival . | Short-term survival N (%) . | Six-month survival N (%)4-150 . | Median survival of short-term survivors . |
|---|---|---|---|---|---|---|
| Crawford et al, 19882 | 232 | Ret coh (1) | One month after MV discontinued | 31 (13) | 12 (39) | NR |
| Torrecilla et al, 19884 | 16 | Ret coh (1) | Hospital discharge | 1 (6) | NR | NR |
| Denardo et al, 198921 | 44 | Ret coh (1) | Hospital discharge | 1 (2) | NR | NR |
| Afessa et al, 199229 | 27 | Ret coh (1) | Not specified | 2 (7) | NR | NR |
| Crawford and Peterson, 19921 | 348 | Ret coh (1) | Hospital discharge | 15 (4) | 10 (66) | NR |
| Paz et al, 199330 | 28 | Ret coh (1) | ICU discharge | 1 (4) | NR | NR |
| Faber-Langendoen et al, 19938 | 191 | Ret coh (1) | One month after MV discontinued | 16 (8) | 6 (38) | NR |
| Rubenfeld and Crawford, 19963 | 865 | NCC (1) | One month after hospital discharge | 53 (6) | 35 (66) | 634 days |
| Epner et al, 199632 | 71 | Ret coh (1) | Hospital discharge | 7 (10) | NR | NR |
| Hollmig et al, 19975 | 10 | Ret coh (1) | ICU discharge | 4 (40) | NR | NR |
| Jackson et al, 199831 | 92 | Ret coh (1) | Discharge from hospital | 16 (17) | 14 (88) | NR |
| Price et al,4-151199823 | 48 | Pro coh (1) | Discharge from hospital | 9 (19) | NR | NR |
| Ewig et al, 199828 | 50 | Ret coh (1) | ICU discharge | 2 (4-5)‡ | NR | NR |
| Shorr et al, 199933 | 17 | Pro coh (1) | Hospital discharge | 3 (18) | NR | NR |
| Huaringa et al, 200027 | 60 | Ret coh (1) | ICU discharge | 11 (18) | 3 (27) | NR |
| Validation cohort | 226 | Pro coh (5) | Discharge from hospital | 32 (14) | 20 (63) | 451 days |
| One month after hospital discharge | 30 (13) | 20 (67) |
Ret Coh indicates retrospective cohort; Pro coh, prospective cohort; NCC, nested case-control; NR; not reported.
Percentage reflects the proportion of patients surviving 6 months conditioned on surviving to the short-term survival endpoint.
Study performed on a subset of validation cohort.
Denominator could not be determined exactly, but was in the range of 39 to 49.