C-myc rearrangements in patients
| Diagnosis . | Germline c-myc* . | Classic t(8;14) . | Classic t(8;22) . | Other c-myc partners . | Nonclassic t(8;14)† . | All c-myc rearrangements . |
|---|---|---|---|---|---|---|
| New MM | 449 | 11 | 8 | 61 | 2 | 82/529 (16) |
| Relapsed MM | 53 | 1 | 0 | 4 | 1 | 6/58 (10) |
| Primary PCL | 20 | 0 | 0 | 3 | 0 | 3/23 (13) |
| MGUS | 63 | 0 | 0 | 2 | 0 | 2/65 (3) |
| SMM | 23 | 0 | 0 | 1 | 0 | 1/24 (4) |
| Diagnosis . | Germline c-myc* . | Classic t(8;14) . | Classic t(8;22) . | Other c-myc partners . | Nonclassic t(8;14)† . | All c-myc rearrangements . |
|---|---|---|---|---|---|---|
| New MM | 449 | 11 | 8 | 61 | 2 | 82/529 (16) |
| Relapsed MM | 53 | 1 | 0 | 4 | 1 | 6/58 (10) |
| Primary PCL | 20 | 0 | 0 | 3 | 0 | 3/23 (13) |
| MGUS | 63 | 0 | 0 | 2 | 0 | 2/65 (3) |
| SMM | 23 | 0 | 0 | 1 | 0 | 1/24 (4) |
Values are numbers (%) of patients.
New MM indicates newly diagnosed multiple myeloma (MM); PCL, primary plasma cell leukemia; MGUS, monoclonal gammopathy of undetermined significance; and SMM, smoldering MM.
Germline c-myc indicates that no rearrangement was observed with use of the set of c-myc telomeric and centromeric probes.
Nonclassic t(8;14) refers to patients who hadc-myc–IgH fusion but lacked any c-mycrearrangement on analysis with the c-myc telomeric andc-myc centromeric set of probes.