Hematopoietic recovery and donor cord blood engraftment as measured by FISH or STR
| Months after BMT . | Patient no. 1 . | Patient no. 2 . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| WBC × 103/μL . | ANC × 103/μL . | Hb g/dL . | PLT × 103μL . | % donor . | WBC × 103/μL . | ANC × 103/μL . | Hb g/dL . | PLT × 103/μL . | % donor . | |
| 0.5 | 3.5 | 2.6 | 10.8* | 29* | 6.5 (FISH) | .2 | .11 | 9.2* | 19* | 93 (FISH) |
| 1.5 | 1.3 | 0.62 | 12.4 | 19* | 18 (FISH) | 7.7 | 3.5 | 10.9 | 8* | 100 (FISH) |
| 3 | 4.7 | 3.48 | 12.8 | 92 | 100 (FISH) | 4.3 | 2.5 | 10.2 | 8* | 100 (STR) |
| 6 | 6.2 | 4.40 | 10.2 | 123 | 100 (FISH) | 19 | 16.0 | 11.0 | 95 | 100 (STR) |
| 12 | 10.2 | 7.34 | 12.4 | 173 | 100 (STR) | — | — | — | — | — |
| Months after BMT . | Patient no. 1 . | Patient no. 2 . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| WBC × 103/μL . | ANC × 103/μL . | Hb g/dL . | PLT × 103μL . | % donor . | WBC × 103/μL . | ANC × 103/μL . | Hb g/dL . | PLT × 103/μL . | % donor . | |
| 0.5 | 3.5 | 2.6 | 10.8* | 29* | 6.5 (FISH) | .2 | .11 | 9.2* | 19* | 93 (FISH) |
| 1.5 | 1.3 | 0.62 | 12.4 | 19* | 18 (FISH) | 7.7 | 3.5 | 10.9 | 8* | 100 (FISH) |
| 3 | 4.7 | 3.48 | 12.8 | 92 | 100 (FISH) | 4.3 | 2.5 | 10.2 | 8* | 100 (STR) |
| 6 | 6.2 | 4.40 | 10.2 | 123 | 100 (FISH) | 19 | 16.0 | 11.0 | 95 | 100 (STR) |
| 12 | 10.2 | 7.34 | 12.4 | 173 | 100 (STR) | — | — | — | — | — |
The STR analyses were carried out separately on lymphoid and myeloid preparations. Both fractions showed complete donor hematopoiesis.
BMT indicates bone marrow transplantation; WBC, white blood count; Hb, hemoglobin level.
Transfusions continued pro re nata (as necessary).