Table 3. Fludarabine augments the... | American Society of Hematology

Table 3.

Fludarabine augments the myelotoxicity of total body irradiation

Group	Flu 100 mg/kg IP d −6 to −2	200 cGy TBI d −1	Cy 200 mg/kg IP d 3	Mean % total donor chimerism (SEM)	Mean % T-cell chimerism (SEM)	Mean % B-cell chimerism (SEM)
1^*	+	−	−	<1	Undetectable	Undetectable
2	−	+	−	48.17 (4.82)	46.38 (5.34)	45.26 (5.92)
3	+	+	−	68.66 (6.32)^†	67.56 (5.49)^†	70.43 (7.18)^†

Group	Flu 100 mg/kg IP d −6 to −2	200 cGy TBI d −1	Cy 200 mg/kg IP d 3	Mean % total donor chimerism (SEM)	Mean % T-cell chimerism (SEM)	Mean % B-cell chimerism (SEM)
1^*	+	−	−	<1	Undetectable	Undetectable
2	−	+	−	48.17 (4.82)	46.38 (5.34)	45.26 (5.92)
3	+	+	−	68.66 (6.32)^†	67.56 (5.49)^†	70.43 (7.18)^†

Flu indicates fludarabine; IP, intraperitoneal; TBI, total body irradiation; Cy, cyclophosphamide;

n = 5 per group.

P < .05 compared with group 2 (unpaired Student t test).