Table 1. Patient clinical and laboratory... | American Society of Hematology

Table 1.

Patient clinical and laboratory features and associated FISH results

No.	Sex	Age	IgH status	BM PC (%)	κ:λ ratio	Heavy chain	Serum M spike (g/dL)	Urine M spike (g/24 h)	V_H/C_H				t(11;14)(q13;q32)
No.	Sex	Age	IgH status	BM PC (%)	κ:λ ratio	Heavy chain	Serum M spike (g/dL)	Urine M spike (g/24 h)	Pattern	Positive (%)	Equivocal (%)	Positive and equivocal	Pattern	Positive (%)
Newly diagnosed patients
1	M	63	t(11;14)	19	< 1:99	ND	IF	1.5	1F1R1G	89	11	100	2F1G2R	100
2	F	78	t(11;14)	8	1:40	IgG	0.6	0.9	1F1R1G	84	8	92	1F1G2R	86
3	F	51	t(11;14)	33	< 1:99	ND	IF	IF	1F1R1G	79	8	87	1F1G2R	89
4	F	62	t(11;14)	12	1:2	IgG	0.4	IF	1F1R1G	75	6	81	1F2R	100
5	M	71	t(11;14)	4	1:4	ND	ND	IF	1F1R1G	66	10	76	1F1R1G	68
6	M	62	t(11;14)	13	1:54	IgG	0.8	ND	1F1R1G	57	30	87	1F1R1G	95
7	M	53	t(11;14)	22	> 99:1	ND	ND	IF	1F1R1G	55	31	86	1F1G2R	85
8	M	57	t(11;14)	26	> 99:1	IgA	IF	IF	1F1R1G	54	36	90	1F2R	85
9	M	77	t(11;14)	1	1:1	IgG	ND	0.7 (λ)	1F1R1G	53	19	72	1F1G1R	71
10	M	65	t(11;14)	10	1:4	ND	ND	ND	1F1R1G	38	30	68	1F1G1R	95
11	M	63	t(11;14)	3	< 1:99	ND	IF	3	1F1R1G	30	59	89	1F1G3R	93
12	M	75	t(11;14)	25	> 99:1	IgG	1.6	1.5	1F1R1G	28	68	96	1F2R1G	72
13	M	40	t(11;14)	8.8	1:44	ND	IF	IF	1F1G	21	69	90	1F2R	68
14	M	41	t(11;14)	5	1:25	ND	ND	0.5	1F1G	19	66	85	1F2R1G	96
15	M	74	14q32+	10	1:60	IgA	0.7	1.2	1F1R1G	41	35	76	2G2R	15
16	F	67	14q32+	1	1:1	ND	IF	IF (λ)	1F1R1G	38	14	52	2G2R	19
17	F	57	14q32+	1	< 1:99	ND	ND	IF	1F1R1G	27	17	44	2G2R	18
18	F	58	Equivocal^*	3	1:13	IgG	1.7	IF	2F1G	7	83	90	2G2R	10
19	M	67	Negative	4.6	< 1:99	IgA	ND	IF	2F	18	14	32	Fail	—
20	M	64	Negative	9	1:23	IgG	0.9	IF	2F	9	18	27	2G2R	16
21	F	37	Negative	15	18:1	ND	ND	IF	2F	23	19	42	2G2R	15
22	M	65	Negative^†	13	1:13	ND	ND	ND	2F	20	20	40	Fail	—
23	M	60	Negative	38	> 99:1	IgA	2.5	ND	2F	19	24	43	2G2R	13
24	F	70	Negative	34	< 1:99	IgA	1.2	IF	2F	14	11	25	2G2R	23
Patients with previous alkylator chemotherapy
25	M	74	t(11;14)	5	4:1	ND	ND	ND	1F1G	25	65	90	1F1G2R	72
26	F	45	t(11;14)	17	< 1:99	IgG	IF	0.05	2F1G	12	64	76	1F1G2R	80
27	F	55	14q32+	3	< 1:99	IgA	0.5	ND	1F1R1G	75	16	91	2G2R	15
28	M	54	Negative	10	1:1	IgM	0.8	0.07 (λ)	2F	15	19	34	2G2R	23
29	M	54	Negative^‡	22	> 99:1	IgG	1	0.2	2F	7	9	16	Fail	—

No.	Sex	Age	IgH status	BM PC (%)	κ:λ ratio	Heavy chain	Serum M spike (g/dL)	Urine M spike (g/24 h)	V_H/C_H				t(11;14)(q13;q32)
No.	Sex	Age	IgH status	BM PC (%)	κ:λ ratio	Heavy chain	Serum M spike (g/dL)	Urine M spike (g/24 h)	Pattern	Positive (%)	Equivocal (%)	Positive and equivocal	Pattern	Positive (%)
Newly diagnosed patients
1	M	63	t(11;14)	19	< 1:99	ND	IF	1.5	1F1R1G	89	11	100	2F1G2R	100
2	F	78	t(11;14)	8	1:40	IgG	0.6	0.9	1F1R1G	84	8	92	1F1G2R	86
3	F	51	t(11;14)	33	< 1:99	ND	IF	IF	1F1R1G	79	8	87	1F1G2R	89
4	F	62	t(11;14)	12	1:2	IgG	0.4	IF	1F1R1G	75	6	81	1F2R	100
5	M	71	t(11;14)	4	1:4	ND	ND	IF	1F1R1G	66	10	76	1F1R1G	68
6	M	62	t(11;14)	13	1:54	IgG	0.8	ND	1F1R1G	57	30	87	1F1R1G	95
7	M	53	t(11;14)	22	> 99:1	ND	ND	IF	1F1R1G	55	31	86	1F1G2R	85
8	M	57	t(11;14)	26	> 99:1	IgA	IF	IF	1F1R1G	54	36	90	1F2R	85
9	M	77	t(11;14)	1	1:1	IgG	ND	0.7 (λ)	1F1R1G	53	19	72	1F1G1R	71
10	M	65	t(11;14)	10	1:4	ND	ND	ND	1F1R1G	38	30	68	1F1G1R	95
11	M	63	t(11;14)	3	< 1:99	ND	IF	3	1F1R1G	30	59	89	1F1G3R	93
12	M	75	t(11;14)	25	> 99:1	IgG	1.6	1.5	1F1R1G	28	68	96	1F2R1G	72
13	M	40	t(11;14)	8.8	1:44	ND	IF	IF	1F1G	21	69	90	1F2R	68
14	M	41	t(11;14)	5	1:25	ND	ND	0.5	1F1G	19	66	85	1F2R1G	96
15	M	74	14q32+	10	1:60	IgA	0.7	1.2	1F1R1G	41	35	76	2G2R	15
16	F	67	14q32+	1	1:1	ND	IF	IF (λ)	1F1R1G	38	14	52	2G2R	19
17	F	57	14q32+	1	< 1:99	ND	ND	IF	1F1R1G	27	17	44	2G2R	18
18	F	58	Equivocal^*	3	1:13	IgG	1.7	IF	2F1G	7	83	90	2G2R	10
19	M	67	Negative	4.6	< 1:99	IgA	ND	IF	2F	18	14	32	Fail	—
20	M	64	Negative	9	1:23	IgG	0.9	IF	2F	9	18	27	2G2R	16
21	F	37	Negative	15	18:1	ND	ND	IF	2F	23	19	42	2G2R	15
22	M	65	Negative^†	13	1:13	ND	ND	ND	2F	20	20	40	Fail	—
23	M	60	Negative	38	> 99:1	IgA	2.5	ND	2F	19	24	43	2G2R	13
24	F	70	Negative	34	< 1:99	IgA	1.2	IF	2F	14	11	25	2G2R	23
Patients with previous alkylator chemotherapy
25	M	74	t(11;14)	5	4:1	ND	ND	ND	1F1G	25	65	90	1F1G2R	72
26	F	45	t(11;14)	17	< 1:99	IgG	IF	0.05	2F1G	12	64	76	1F1G2R	80
27	F	55	14q32+	3	< 1:99	IgA	0.5	ND	1F1R1G	75	16	91	2G2R	15
28	M	54	Negative	10	1:1	IgM	0.8	0.07 (λ)	2F	15	19	34	2G2R	23
29	M	54	Negative^‡	22	> 99:1	IgG	1	0.2	2F	7	9	16	Fail	—

F indicates fusion; G, green; R, red; 14q32+, IgH translocation without partner identified; IF, immunofixation; ND, not detected.

Equivocal for 14q32 and negative for t(11;14).

†

Patient with monosomy of chromosome 14 in 55% of PCs.

‡

Patient with monosomy of chromosome 14 in 76% of PCs.

View Large

This Feature Is Available To Subscribers Only