Table 1. Synopsis of receptor phenotypes... | American Society of Hematology

Table 1.

Synopsis of receptor phenotypes

Receptor	Tyrosine phosphorylation (basal/stimulated)	lck association (basal/stimulated)	ZAP-70 phosphorylation (stimulated)	Calcium flux (stimulated)	IL-2 production (sensitivity)	IL-2 production (potency)	IL-2 production (low-affinity ligand)
K^b-ζ	−/+	−/−	−	+	+	+	+
K^b-CD4-ζ	−/++	+/+++	++	+	++	++	+
				(rapid rise)
K^b-ζ-lck	+/+++	−/−	+++	+	++	++	+
				(rapid rise)
K^b-CD28-ζ	−/++	−/+	−	+	++	++	++
				(protracted flux)
K^b-CD28-ζ-lck	+/+++	−/+	+++	++	+++	+++	+++
				(rapid rise and protracted flux)

Receptor	Tyrosine phosphorylation (basal/stimulated)	lck association (basal/stimulated)	ZAP-70 phosphorylation (stimulated)	Calcium flux (stimulated)	IL-2 production (sensitivity)	IL-2 production (potency)	IL-2 production (low-affinity ligand)
K^b-ζ	−/+	−/−	−	+	+	+	+
K^b-CD4-ζ	−/++	+/+++	++	+	++	++	+
				(rapid rise)
K^b-ζ-lck	+/+++	−/−	+++	+	++	++	+
				(rapid rise)
K^b-CD28-ζ	−/++	−/+	−	+	++	++	++
				(protracted flux)
K^b-CD28-ζ-lck	+/+++	−/+	+++	++	+++	+++	+++
				(rapid rise and protracted flux)

Responses of receptors are qualitatively summarized based on data in Figures 3 through 6.