Criteria for treatment response as assessed after (or within) 6 courses
| . | Criterion . |
|---|---|
| Clinical remission | |
| Lymph node, spleen, and liver enlargement (clinical) | Absent |
| Lymphocytosis | < 4.109/L |
| Neutrophils | ≥ 1.5 109/L |
| Platelets | ≥ 100 109/L |
| Hemoglobin level | ≥ 110 g/L |
| Partial remission | |
| Decrease in lymph node, spleen, and liver enlargement | > 50% |
| Decrease in lymphocytosis | > 50% from baseline value |
| Neutrophils | > 1.5 109/L or increased by 50% from baseline value |
| Platelets | > 100 109/L or increased by 50% from baseline value |
| Hemoglobin level | > 110 g/L or increased by 50% from baseline value |
| Stable disease | |
| Response or progression | Absent |
| Progressive disease | |
| Increase in lymph node, spleen, or liver volume | > 50% or new involvement of these organs |
| Increase in lymphocytosis | > 50% from baseline value |
| Neutrophils | < 1.5 109/L or decreased by 50% from baseline value |
| Platelets | < 100 109/L or decreased by 50% from baseline value |
| Hemoglobin level | < 110 g/L or decreased by 50% from baseline value |
| . | Criterion . |
|---|---|
| Clinical remission | |
| Lymph node, spleen, and liver enlargement (clinical) | Absent |
| Lymphocytosis | < 4.109/L |
| Neutrophils | ≥ 1.5 109/L |
| Platelets | ≥ 100 109/L |
| Hemoglobin level | ≥ 110 g/L |
| Partial remission | |
| Decrease in lymph node, spleen, and liver enlargement | > 50% |
| Decrease in lymphocytosis | > 50% from baseline value |
| Neutrophils | > 1.5 109/L or increased by 50% from baseline value |
| Platelets | > 100 109/L or increased by 50% from baseline value |
| Hemoglobin level | > 110 g/L or increased by 50% from baseline value |
| Stable disease | |
| Response or progression | Absent |
| Progressive disease | |
| Increase in lymph node, spleen, or liver volume | > 50% or new involvement of these organs |
| Increase in lymphocytosis | > 50% from baseline value |
| Neutrophils | < 1.5 109/L or decreased by 50% from baseline value |
| Platelets | < 100 109/L or decreased by 50% from baseline value |
| Hemoglobin level | < 110 g/L or decreased by 50% from baseline value |