Protocol follow-up on 938 randomized patients
| . | ChOP, no.* . | CAP, no.† . | FAMP, no.‡ . |
|---|---|---|---|
| Did not receive scheduled chemotherapy as allocated (reason) | 11 | 8 | 5 |
| Early death2-153 | 2 | 1 | 1 |
| Patient refusal | 2 | 1 | 1 |
| Lost to follow-up | 4 | 2 | 2 |
| Stage A improved | 2 | 1 | — |
| Richter syndrome2-155 | 1 | — | 1 |
| Contraindication | — | 3 | — |
| Received 1 or 2 courses of scheduled chemotherapy as allocated (reason) | 2 | 7 | 4 |
| Early death2-153 | 3 | 3 | 3 |
| Therapy ineffective2-153 | 3 | 2 | 2 |
| Toxicity | 2 | — | 1 |
| Lost to follow-up | 1 | — | 1 |
| Patient refusal | |||
| Completed at least 3 courses of scheduled chemotherapy | 335 | 220 | 308 |
| Switches at third to sixth course2-154 | 41 | 56 | 31 |
| . | ChOP, no.* . | CAP, no.† . | FAMP, no.‡ . |
|---|---|---|---|
| Did not receive scheduled chemotherapy as allocated (reason) | 11 | 8 | 5 |
| Early death2-153 | 2 | 1 | 1 |
| Patient refusal | 2 | 1 | 1 |
| Lost to follow-up | 4 | 2 | 2 |
| Stage A improved | 2 | 1 | — |
| Richter syndrome2-155 | 1 | — | 1 |
| Contraindication | — | 3 | — |
| Received 1 or 2 courses of scheduled chemotherapy as allocated (reason) | 2 | 7 | 4 |
| Early death2-153 | 3 | 3 | 3 |
| Therapy ineffective2-153 | 3 | 2 | 2 |
| Toxicity | 2 | — | 1 |
| Lost to follow-up | 1 | — | 1 |
| Patient refusal | |||
| Completed at least 3 courses of scheduled chemotherapy | 335 | 220 | 308 |
| Switches at third to sixth course2-154 | 41 | 56 | 31 |
Total, 357.
Total, 240.
Total, 341.
Early deaths and early stops due to inefficacy were considered as treatment failures.
Diagnosis is based on needle lymph node aspiration and aspect of large cell lymphoma on histologic examination.
Due to treatment inefficacy and thus considered as treatment failures.