Baseline comparison of randomized groups according to stage and treatment
| . | Stage B . | Stage C . | ||||
|---|---|---|---|---|---|---|
| ChOP (n = 240) . | CAP (n = 175) . | FAMP (n = 236) . | ChOP (n = 117) . | CAP (n = 65) . | FAMP (n = 105) . | |
| Age, y (range) | 62 (55-67) | 60 (55-67) | 62 (53-67) | 64 (59-68) | 65 (58-71) | 63 (56-68) |
| Male | 76% | 69% | 74% | 66% | 53% | 69% |
| Involved areas | ||||||
| Cervical | 96% | 95% | 95% | 65% | 73% | 70% |
| Axillary | 94% | 93% | 96% | 62% | 72% | 61% |
| Inguinal | 85% | 78% | 77% | 50% | 53% | 49% |
| Spleen | 52% | 66% | 59% | 75% | 64% | 78% |
| Liver | 12% | 16% | 14% | 15% | 23% | 22% |
| Bulky disease* | 25% | 26% | 24% | 20% | 30% | 33% |
| Hemoglobin (g/L) | 134 (123-143) | 133 (120-143) | 135 (123-145) | 91 (81-101) | 94.5 (82.5-115) | 95 (77-115) |
| Platelets (109/L) | 184 (148-226) | 180 (141-228) | 176 (148-217) | 90 (68-126) | 92.5 (66-125.5) | 88 (71-115) |
| Lymphocytes | ||||||
| Blood (109/L) | 40.7 (19.2-90.2) | 49 (22-90.7) | 50.5 (19-88.3) | 76.3 (31-165) | 59.3 (28-194) | 58.6 (22-111) |
| Medullary (%) | 77 (63-86) | 80 (67-89) | 80 (65-86) | 91 (83-95) | 90 (80.5-94) | 86 (75.5-93.5) |
| . | Stage B . | Stage C . | ||||
|---|---|---|---|---|---|---|
| ChOP (n = 240) . | CAP (n = 175) . | FAMP (n = 236) . | ChOP (n = 117) . | CAP (n = 65) . | FAMP (n = 105) . | |
| Age, y (range) | 62 (55-67) | 60 (55-67) | 62 (53-67) | 64 (59-68) | 65 (58-71) | 63 (56-68) |
| Male | 76% | 69% | 74% | 66% | 53% | 69% |
| Involved areas | ||||||
| Cervical | 96% | 95% | 95% | 65% | 73% | 70% |
| Axillary | 94% | 93% | 96% | 62% | 72% | 61% |
| Inguinal | 85% | 78% | 77% | 50% | 53% | 49% |
| Spleen | 52% | 66% | 59% | 75% | 64% | 78% |
| Liver | 12% | 16% | 14% | 15% | 23% | 22% |
| Bulky disease* | 25% | 26% | 24% | 20% | 30% | 33% |
| Hemoglobin (g/L) | 134 (123-143) | 133 (120-143) | 135 (123-145) | 91 (81-101) | 94.5 (82.5-115) | 95 (77-115) |
| Platelets (109/L) | 184 (148-226) | 180 (141-228) | 176 (148-217) | 90 (68-126) | 92.5 (66-125.5) | 88 (71-115) |
| Lymphocytes | ||||||
| Blood (109/L) | 40.7 (19.2-90.2) | 49 (22-90.7) | 50.5 (19-88.3) | 76.3 (31-165) | 59.3 (28-194) | 58.6 (22-111) |
| Medullary (%) | 77 (63-86) | 80 (67-89) | 80 (65-86) | 91 (83-95) | 90 (80.5-94) | 86 (75.5-93.5) |
Median values (25th-75th percentiles) are given for continuous variables; percentages are reported for categorical variables.
Bulky disease is clinically defined on the basis of at least one lymph node with diameter greater than 4 cm or spleen below the umbilicus or both.