Tumor-to–normal organ ratios of absorbed radiation in Ramos xenograft-bearing mice treated with standard radiolabeled anti-CD20 antibodies or pretargeted radiolabeled biotin
| Tissue . | Time . | |||||
|---|---|---|---|---|---|---|
| 2 h . | 12 h . | 24 h . | 48 h . | 96 h . | 144 h . | |
| Blood | ||||||
| PT | 3.5 ± 0.3 | 4.1 ± 0.9 | 5.7 ± 1.3 | 8.1 ± 1.7 | 15.3 ± 2.9 | 31.9 ± 8.0 |
| Std | 0.3 ± 0.1 | 0.4 ± 0.1 | 0.4 ± 0.1 | 0.5 ± 0.1 | 0.4 ± 0.2 | 0.2 ± 0.1 |
| Kidney | ||||||
| PT | 5.7 ± 0.7 | 7.9 ± 2.5 | 7.8 ± 1.1 | 8.0 ± 4.2 | 5.5 ± 1.1 | 3.4 ± 1.0 |
| Std | 0.9 ± 0.3 | 1.5 ± 0.2 | 1.7 ± 0.3 | 2.4 ± 0.4 | 1.6 ± 0.6 | 0.7 ± 0.2 |
| Liver | ||||||
| PT | 8.8 ± 1.0 | 9.5 ± 2.4 | 12.5 ± 2.3 | 14.5 ± 6.6 | 9.8 ± 2.1 | 11.4 ± 3.8 |
| Std | 1.2 ± 0.4 | 1.7 ± 0.3 | 2.3 ± 0.6 | 3.5 ± 0.6 | 2.1 ± 0.8 | 1.0 ± 0.3 |
| Lung | ||||||
| PT | 7.0 ± 0.8 | 9.3 ± 2.5 | 12.0 ± 2.6 | 16.7 ± 6.2 | 14.3 ± 2.6 | 12.9 ± 4.8 |
| Std | 0.9 ± 0.3 | 1.0 ± 0.1 | 1.1 ± 0.8 | 1.4 ± 0.3 | 1.0 ± 0.4 | 0.4 ± 0.7 |
| Muscle | ||||||
| PT | 7.7 ± 1.6 | 23.1 ± 4.6 | 32.2 ± 7.0 | 49.4 ± 16.8 | 25.3 ± 4.8 | 21.6 ± 8.4 |
| Std | 0.7 ± 0.4 | 2.1 ± 0.4 | 4.8 ± 0.8 | 6.1 ± 1.1 | 5.9 ± 2.4 | 2.4 ± 0.7 |
| Intestine | ||||||
| PT | 22.5 ± 1.3 | 39.2 ± 14.7 | 38.2 ± 11.4 | 56.0 ± 32.8 | 33.2 ± 5.7 | 24.7 ± 7.4 |
| Std | 1.4 ± 0.5 | 3.0 ± 0.5 | 3.1 ± 0.8 | 4.3 ± 0.7 | 3.6 ± 1.4 | 1.6 ± 0.4 |
| Colon | ||||||
| PT | 22.0 ± 2.6 | 26.7 ± 9.8 | 43.1 ± 10.2 | 45.8 ± 22.4 | 28.9 ± 5.4 | 18.0 ± 4.7 |
| Std | 1.3 ± 0.4 | 2.7 ± 0.5 | 1.3 ± 0.6 | 4.7 ± 1.1 | 3.8 ± 1.6 | 1.4 ± 0.4 |
| Spleen | ||||||
| PT | 12.5 ± 1.6 | 13.9 ± 4.2 | 16.7 ± 3.2 | 15.8 ± 6.0 | 9.2 ± 1.6 | 6.1 ± 1.7 |
| Std | 0.6 ± 0.1 | 1.1 ± 0.2 | 1.3 ± 0.3 | 1.9 ± 0.3 | 1.5 ± 0.5 | 0.8 ± 0.2 |
| Stomach | ||||||
| PT | 21.2 ± 2.0 | 35.5 ± 12.2 | 37.6 ± 6.4 | 38.2 ± 10.0 | 26.8 ± 4.7 | 24.0 ± 6.5 |
| Std | 1.7 ± 0.6 | 3.0 ± 0.5 | 2.8 ± 0.3 | 3.6 ± 0.7 | 3.5 ± 1.2 | 1.3 ± 0.3 |
| Marrow | ||||||
| PT | 8.0 ± 0.7 | 14.2 ± 3.6 | 12.3 ± 2.1 | 14.9 ± 5.2 | 9.0 ± 2.2 | 6.6 ± 1.6 |
| Std | 0.6 ± 0.1 | 1.4 ± 0.4 | 1.3 ± 0.2 | 2.2 ± 0.4 | 1.4 ± 0.5 | 0.6 ± 0.2 |
| Tissue . | Time . | |||||
|---|---|---|---|---|---|---|
| 2 h . | 12 h . | 24 h . | 48 h . | 96 h . | 144 h . | |
| Blood | ||||||
| PT | 3.5 ± 0.3 | 4.1 ± 0.9 | 5.7 ± 1.3 | 8.1 ± 1.7 | 15.3 ± 2.9 | 31.9 ± 8.0 |
| Std | 0.3 ± 0.1 | 0.4 ± 0.1 | 0.4 ± 0.1 | 0.5 ± 0.1 | 0.4 ± 0.2 | 0.2 ± 0.1 |
| Kidney | ||||||
| PT | 5.7 ± 0.7 | 7.9 ± 2.5 | 7.8 ± 1.1 | 8.0 ± 4.2 | 5.5 ± 1.1 | 3.4 ± 1.0 |
| Std | 0.9 ± 0.3 | 1.5 ± 0.2 | 1.7 ± 0.3 | 2.4 ± 0.4 | 1.6 ± 0.6 | 0.7 ± 0.2 |
| Liver | ||||||
| PT | 8.8 ± 1.0 | 9.5 ± 2.4 | 12.5 ± 2.3 | 14.5 ± 6.6 | 9.8 ± 2.1 | 11.4 ± 3.8 |
| Std | 1.2 ± 0.4 | 1.7 ± 0.3 | 2.3 ± 0.6 | 3.5 ± 0.6 | 2.1 ± 0.8 | 1.0 ± 0.3 |
| Lung | ||||||
| PT | 7.0 ± 0.8 | 9.3 ± 2.5 | 12.0 ± 2.6 | 16.7 ± 6.2 | 14.3 ± 2.6 | 12.9 ± 4.8 |
| Std | 0.9 ± 0.3 | 1.0 ± 0.1 | 1.1 ± 0.8 | 1.4 ± 0.3 | 1.0 ± 0.4 | 0.4 ± 0.7 |
| Muscle | ||||||
| PT | 7.7 ± 1.6 | 23.1 ± 4.6 | 32.2 ± 7.0 | 49.4 ± 16.8 | 25.3 ± 4.8 | 21.6 ± 8.4 |
| Std | 0.7 ± 0.4 | 2.1 ± 0.4 | 4.8 ± 0.8 | 6.1 ± 1.1 | 5.9 ± 2.4 | 2.4 ± 0.7 |
| Intestine | ||||||
| PT | 22.5 ± 1.3 | 39.2 ± 14.7 | 38.2 ± 11.4 | 56.0 ± 32.8 | 33.2 ± 5.7 | 24.7 ± 7.4 |
| Std | 1.4 ± 0.5 | 3.0 ± 0.5 | 3.1 ± 0.8 | 4.3 ± 0.7 | 3.6 ± 1.4 | 1.6 ± 0.4 |
| Colon | ||||||
| PT | 22.0 ± 2.6 | 26.7 ± 9.8 | 43.1 ± 10.2 | 45.8 ± 22.4 | 28.9 ± 5.4 | 18.0 ± 4.7 |
| Std | 1.3 ± 0.4 | 2.7 ± 0.5 | 1.3 ± 0.6 | 4.7 ± 1.1 | 3.8 ± 1.6 | 1.4 ± 0.4 |
| Spleen | ||||||
| PT | 12.5 ± 1.6 | 13.9 ± 4.2 | 16.7 ± 3.2 | 15.8 ± 6.0 | 9.2 ± 1.6 | 6.1 ± 1.7 |
| Std | 0.6 ± 0.1 | 1.1 ± 0.2 | 1.3 ± 0.3 | 1.9 ± 0.3 | 1.5 ± 0.5 | 0.8 ± 0.2 |
| Stomach | ||||||
| PT | 21.2 ± 2.0 | 35.5 ± 12.2 | 37.6 ± 6.4 | 38.2 ± 10.0 | 26.8 ± 4.7 | 24.0 ± 6.5 |
| Std | 1.7 ± 0.6 | 3.0 ± 0.5 | 2.8 ± 0.3 | 3.6 ± 0.7 | 3.5 ± 1.2 | 1.3 ± 0.3 |
| Marrow | ||||||
| PT | 8.0 ± 0.7 | 14.2 ± 3.6 | 12.3 ± 2.1 | 14.9 ± 5.2 | 9.0 ± 2.2 | 6.6 ± 1.6 |
| Std | 0.6 ± 0.1 | 1.4 ± 0.4 | 1.3 ± 0.2 | 2.2 ± 0.4 | 1.4 ± 0.5 | 0.6 ± 0.2 |
Std indicates standard radiolabeled anti-CD20 antibodies; PT, pretargeted radiolabeled biotin.