Cox proportional hazards model for survival: multivariate analysis
| Prognostic factor . | PFS . | OS . | ||||
|---|---|---|---|---|---|---|
| Hazard ratio . | 95% CI . | P . | Hazard ratio . | 95% CI . | P . | |
| Chemoresistance at BMT | 9.2 | 3, 31 | .0003 | 8.9 | 1.4, 59 | .02 |
| Type of lymphoma | ||||||
| Large-cell B NHL | 0.8 | 0.2, 3.6 | .8 | 2.2 | 0.2, 22 | .5 |
| Follicular NHL | 0.4 | 0, 2 | .3 | 0.35 | 0, 7 | .5 |
| Hodgkin | 0.3 | 0, 1.7 | .2 | 1 | 0.1, 13 | .99 |
| Relapse category | ||||||
| Primary refractory | 0.5 | 0.1, 2 | .3 | 1.1 | 0.1, 9 | .9 |
| Relapse less than 1 y | 0.6 | 0.2, 2 | .4 | 0.64 | 0.1, 5.5 | .7 |
| Mobilization arm (G-CSF) | 1.2 | 0.4, 3.5 | .7 | 1.1 | 0.2, 5.4 | .9 |
| Prognostic factor . | PFS . | OS . | ||||
|---|---|---|---|---|---|---|
| Hazard ratio . | 95% CI . | P . | Hazard ratio . | 95% CI . | P . | |
| Chemoresistance at BMT | 9.2 | 3, 31 | .0003 | 8.9 | 1.4, 59 | .02 |
| Type of lymphoma | ||||||
| Large-cell B NHL | 0.8 | 0.2, 3.6 | .8 | 2.2 | 0.2, 22 | .5 |
| Follicular NHL | 0.4 | 0, 2 | .3 | 0.35 | 0, 7 | .5 |
| Hodgkin | 0.3 | 0, 1.7 | .2 | 1 | 0.1, 13 | .99 |
| Relapse category | ||||||
| Primary refractory | 0.5 | 0.1, 2 | .3 | 1.1 | 0.1, 9 | .9 |
| Relapse less than 1 y | 0.6 | 0.2, 2 | .4 | 0.64 | 0.1, 5.5 | .7 |
| Mobilization arm (G-CSF) | 1.2 | 0.4, 3.5 | .7 | 1.1 | 0.2, 5.4 | .9 |
Patients with chemoresistant disease at transplantation had a 9-fold increased risk for disease progression (P = .0003) and a 9-fold risk for death (P = .02), compared with those with chemosensitive disease. This is after adjusting for other variables such as the type of lymphoma, presence of refractory disease, and type of mobilization. These other factors were not significant predictors of disease progression or survival.