Pharmacokinetic parameters
| Dose group (mg/kg) . | Value . | Cmax (ng/mL) . | Tmax(h) . | AUC (0-∞) (ng/h · mL) . | Vss(mL/kg) . | CL (mL/h · kg) . | t1/2 (h) . |
|---|---|---|---|---|---|---|---|
| 0.01 (n = 5)8-150 | Mean | 113 | 2.11 | — | — | — | — |
| SD | 107 | 0.47 | — | — | — | — | |
| 0.1 (n = 2) | Mean | 304 | 3.46 | 5 713 | 377.2 | 27.39 | 14.6 |
| SD | 90 | 1.47 | 4 854 | 28.7 | 23.27 | 12.1 | |
| 0.2 (n = 4) | Mean | 1087 | 2.31 | 15 952 | 342.7 | 13.20 | 18.5 |
| SD | 716 | 0.25 | 3 914 | 153.3 | 3.68 | 4.0 | |
| 0.3 (n = 1) | Individual | 988 | 4.00 | 14 559 | 478.6 | 20.61 | 16.7 |
| Dose group (mg/kg) . | Value . | Cmax (ng/mL) . | Tmax(h) . | AUC (0-∞) (ng/h · mL) . | Vss(mL/kg) . | CL (mL/h · kg) . | t1/2 (h) . |
|---|---|---|---|---|---|---|---|
| 0.01 (n = 5)8-150 | Mean | 113 | 2.11 | — | — | — | — |
| SD | 107 | 0.47 | — | — | — | — | |
| 0.1 (n = 2) | Mean | 304 | 3.46 | 5 713 | 377.2 | 27.39 | 14.6 |
| SD | 90 | 1.47 | 4 854 | 28.7 | 23.27 | 12.1 | |
| 0.2 (n = 4) | Mean | 1087 | 2.31 | 15 952 | 342.7 | 13.20 | 18.5 |
| SD | 716 | 0.25 | 3 914 | 153.3 | 3.68 | 4.0 | |
| 0.3 (n = 1) | Individual | 988 | 4.00 | 14 559 | 478.6 | 20.61 | 16.7 |
In the 0.01-mg/kg dose group, Cmax and Tmax were determined in 5 subjects; data were insufficient to determine AUC0-∞, Vss, CL, and t1/2 for the 0.01 mg/kg dose.