Table 1. Patient profiles and the... | American Society of Hematology

Table 1.

Patient profiles and the reactivity of their autoantibodies with mutant GPIIb-IIIa

Patient no.	Age (y)	Sex (M/F)	Plt count (× 10³/μL)	ΔOD^* for WT	ΔOD ratio^† [KO/WT] (%)	ΔOD ratio^†[CAM/WT] (%)
1	40	F	23	1.287	33.4	101.7
2	45	M	53	1.152	98.0	97.2
3	73	F	81	1.148	6.5	99.0
4	43	F	28	1.003	45.9	89.2
5	49	M	39	1.001	92.4	ND
6	47	F	96	0.981	30.0	97.2
7	56	F	43	0.968	94.0	94.8
8	41	M	42	0.894	45.9	100.8
9	35	F	18	0.859	18.6	89.6
10	35	F	43	0.815	111.9	ND
11	32	F	65	0.806	107.6	ND
12	53	F	12	0.719	92.4	99.4
13	49	F	64	0.680	45.5	91.7
14	51	F	51	0.665	90.1	84.3
15	28	F	84	0.619	89.7	ND
16	32	F	55	0.565	92.4	ND
17	57	F	20	0.554	87.4	ND
18	77	F	34	0.551	72.4	91.3
19	67	F	37	0.476	23.7	124.0
20	69	F	106	0.432	71.1	ND
21	62	M	34	0.424	101.9	ND
22	30	F	66	0.392	80.4	87.7
23	34	F	42	0.330	128.9	ND
24	80	F	17	0.281	42.0	117.6
25	77	F	27	0.270	38.9	87.7
26	59	F	29	0.232	87.9	96.3
27	51	F	76	0.205	99.5	116.9
28	61	M	60	0.196	114.8	ND
29	72	F	77	0.184	123.4	111.9
30	58	F	34	0.162	76.5	ND
31	62	F	50	0.160	72.5	88.0
32	60	F	17	0.148	41.9	125.6
33	50	F	23	0.147	84.3	ND
34	55	F	26	0.088	73.8	ND

Patient no.	Age (y)	Sex (M/F)	Plt count (× 10³/μL)	ΔOD^* for WT	ΔOD ratio^† [KO/WT] (%)	ΔOD ratio^†[CAM/WT] (%)
1	40	F	23	1.287	33.4	101.7
2	45	M	53	1.152	98.0	97.2
3	73	F	81	1.148	6.5	99.0
4	43	F	28	1.003	45.9	89.2
5	49	M	39	1.001	92.4	ND
6	47	F	96	0.981	30.0	97.2
7	56	F	43	0.968	94.0	94.8
8	41	M	42	0.894	45.9	100.8
9	35	F	18	0.859	18.6	89.6
10	35	F	43	0.815	111.9	ND
11	32	F	65	0.806	107.6	ND
12	53	F	12	0.719	92.4	99.4
13	49	F	64	0.680	45.5	91.7
14	51	F	51	0.665	90.1	84.3
15	28	F	84	0.619	89.7	ND
16	32	F	55	0.565	92.4	ND
17	57	F	20	0.554	87.4	ND
18	77	F	34	0.551	72.4	91.3
19	67	F	37	0.476	23.7	124.0
20	69	F	106	0.432	71.1	ND
21	62	M	34	0.424	101.9	ND
22	30	F	66	0.392	80.4	87.7
23	34	F	42	0.330	128.9	ND
24	80	F	17	0.281	42.0	117.6
25	77	F	27	0.270	38.9	87.7
26	59	F	29	0.232	87.9	96.3
27	51	F	76	0.205	99.5	116.9
28	61	M	60	0.196	114.8	ND
29	72	F	77	0.184	123.4	111.9
30	58	F	34	0.162	76.5	ND
31	62	F	50	0.160	72.5	88.0
32	60	F	17	0.148	41.9	125.6
33	50	F	23	0.147	84.3	ND
34	55	F	26	0.088	73.8	ND

ΔOD ratios less than 50% are underlined.

Plt indicates platelet; WT, wild-type GPIIb-IIIa; KO, KO-variant GPIIb-IIIa; CAM, CAM variant GPIIb-IIIa; ND, not done.

[Optical density (OD) value obtained from a test sample] − [(mean + 3 SD) OD value obtained from 5 control samples] in antigen-capture ELISA.

[(ΔOD in antigen-capture ELISA using mutant GPIIb-IIIa)/(ΔOD in antigen-capture ELISA using WT)] × 100.