Meta-analysis estimates for the association of polymorphisms of the low-affinity Fcγ receptors with various disease outcomes
| Outcome (no. of studies) . | FcγRIIa: HH vs HR +RR . | FcγRIIa: RR vs HR +HH . | ||||
|---|---|---|---|---|---|---|
| Heterogeneity P* . | ORr (95% CI) . | ORf (95% CI) . | Heterogeneity P* . | ORr (95% CI) . | ORf (95% CI) . | |
| SLE (12) | .009 | 0.61 (0.44-0.85) | 0.70 (0.57-0.85) | .810 | 1.37 (1.13-1.67) | 1.38 (1.14-1.67) |
| HIT (6) | <.001 | 1.11 (0.56-2.19) | 0.86 (0.69-1.08) | .023 | 0.81 (0.49-1.34) | 1.02 (0.81-1.29) |
| ITP (2) | .067 | 0.81 (0.19-3.50) | 0.92 (0.45-1.87) | .011 | 1.62 (0.24-11.2) | 1.71 (0.87-3.38) |
| SLE nephritis (7) | .156 | 0.71 (0.44-1.14) | 0.68 (0.47-0.98) | .617 | 1.35 (0.97-1.88) | 1.36 (0.98-1.88) |
| FcγRIIIa: FF vs VF+VV | FcγRIIIa: VV vs VF+ FF | |||||
| SLE (2) | .493 | 2.49 (1.67-3.71) | 2.48 (1.66-3.70) | .549 | 0.67 (0.38-1.19) | 0.67 (0.38-1.18) |
| Outcome (no. of studies) . | FcγRIIa: HH vs HR +RR . | FcγRIIa: RR vs HR +HH . | ||||
|---|---|---|---|---|---|---|
| Heterogeneity P* . | ORr (95% CI) . | ORf (95% CI) . | Heterogeneity P* . | ORr (95% CI) . | ORf (95% CI) . | |
| SLE (12) | .009 | 0.61 (0.44-0.85) | 0.70 (0.57-0.85) | .810 | 1.37 (1.13-1.67) | 1.38 (1.14-1.67) |
| HIT (6) | <.001 | 1.11 (0.56-2.19) | 0.86 (0.69-1.08) | .023 | 0.81 (0.49-1.34) | 1.02 (0.81-1.29) |
| ITP (2) | .067 | 0.81 (0.19-3.50) | 0.92 (0.45-1.87) | .011 | 1.62 (0.24-11.2) | 1.71 (0.87-3.38) |
| SLE nephritis (7) | .156 | 0.71 (0.44-1.14) | 0.68 (0.47-0.98) | .617 | 1.35 (0.97-1.88) | 1.36 (0.98-1.88) |
| FcγRIIIa: FF vs VF+VV | FcγRIIIa: VV vs VF+ FF | |||||
| SLE (2) | .493 | 2.49 (1.67-3.71) | 2.48 (1.66-3.70) | .549 | 0.67 (0.38-1.19) | 0.67 (0.38-1.18) |
Numerical data for the calculations are as presented by Lehrnbecher et al.3
ORf indicates fixed-effects odds ratio; ORf, random-effects odds ratio; SLE, systemic lupus erythematosus; HIT, heparin-induced thrombocytopenia; and ITP, idiopathic thrombocytopenic purpura.
P value for the Q statistic testing for between-study heterogeneity of the odds ratios; heterogeneity is typically considered statistically significant for P < .10.