Table 1. Clinical and laboratory... | American Society of Hematology

Table 1.

Clinical and laboratory findings, HLA class II alleles, β₂GPI genotypes, and the number of β₂GPI-reactive CD4⁺ T cell clones generated in patients with APS

Patient	Age/sex	Clinical findings		Anti-β₂GPI antibody^*(U/mL)	HLA class II alleles					β₂GPI genotype at position 247^†	Number of β₂GPI-specific T-cell clones
Patient	Age/sex	Thrombosis	Pregnancy loss	Anti-β₂GPI antibody^*(U/mL)	DRB1	DRB4	DRB5	DQB1	DPB1	β₂GPI genotype at position 247^†	Number of β₂GPI-specific T-cell clones
O.M.	39/F	Stroke	+	> 125.0	^1501/^0403	^*0103	^*0101	^0602/^0302	^*0201	²⁴⁷L/²⁴⁷L	4
E.Y.	38/F	DVT, PE	N/A	92.9	^*0901	^*0103	—	^*0303	^*0201	²⁴⁷V/²⁴⁷L	4
K.S.	38/F	Stroke	+	> 125.0	^1502/^0901	^*0103	^*0102	^0601/^0303	^0501/^0901	²⁴⁷V/²⁴⁷L	6

Patient	Age/sex	Clinical findings		Anti-β₂GPI antibody^*(U/mL)	HLA class II alleles					β₂GPI genotype at position 247^†	Number of β₂GPI-specific T-cell clones
Patient	Age/sex	Thrombosis	Pregnancy loss	Anti-β₂GPI antibody^*(U/mL)	DRB1	DRB4	DRB5	DQB1	DPB1	β₂GPI genotype at position 247^†	Number of β₂GPI-specific T-cell clones
O.M.	39/F	Stroke	+	> 125.0	^1501/^0403	^*0103	^*0101	^0602/^0302	^*0201	²⁴⁷L/²⁴⁷L	4
E.Y.	38/F	DVT, PE	N/A	92.9	^*0901	^*0103	—	^*0303	^*0201	²⁴⁷V/²⁴⁷L	4
K.S.	38/F	Stroke	+	> 125.0	^1502/^0901	^*0103	^*0102	^0601/^0303	^0501/^0901	²⁴⁷V/²⁴⁷L	6

DVT indicates deep venous thrombosis of lower extremity; PE, pulmonary embolism; N/A, not applicable.

Normal range < 3.5 U/mL.

†

A valine (²⁴⁷V) to leucine (²⁴⁷L) amino acid dimorphism was determined by RsaI digestion of the PCR-amplified DNA.

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