Clinical and virologic characteristics of 50 BMT patients evaluated for HC
| Virologic and laboratory parameters . | Clinical presentation . | . | |
|---|---|---|---|
| No HC . | HC . | ||
| BK viruria (median genome copies/d) | |||
| Free urine | |||
| Peak* | 2.2 × 108 | 2 × 1012 | P< .001† |
| Total | 3.5 × 109 | 3.9 × 1013 | P< .001† |
| Prior to HC‡ | 3.5 × 109 | 1.2 × 1013 | P< .001† |
| Mean daily prior to HC2-153 | 8.0 × 107 | 5.5 × 1011 | P< .001† |
| Urinary sediment | |||
| Peak* | 5.7 × 107 | 6 × 1012 | P< .001† |
| Total | 7.7 × 108 | 4.9 × 1013 | P< .001† |
| Prior to HC | 7.7 × 108 | 8.6 × 1012 | P< .001† |
| Mean daily prior to HC | 2.3 × 107 | 5.3 × 1011 | P< .001† |
| BK viremia | |||
| Median copies/mL | 2.8 × 104 | 3.8 × 104 | P= NS† |
| ADV viruria (median genome copies/d) | |||
| Free urine | 2.2 × 107 | 7.5 × 107 | P= NS† |
| Urinary sediments | 8.3 × 105 | 8.6 × 105 | P= NS† |
| ADV viremia | |||
| Median genome copies/mL | 2.7 × 104 | 3.3 × 104 | P= NS† |
| Serum creatinine (μmol/L)2-155 | |||
| Median (range) | 81 (50-129) | 73 (53-171) | P = NS† |
| Virologic and laboratory parameters . | Clinical presentation . | . | |
|---|---|---|---|
| No HC . | HC . | ||
| BK viruria (median genome copies/d) | |||
| Free urine | |||
| Peak* | 2.2 × 108 | 2 × 1012 | P< .001† |
| Total | 3.5 × 109 | 3.9 × 1013 | P< .001† |
| Prior to HC‡ | 3.5 × 109 | 1.2 × 1013 | P< .001† |
| Mean daily prior to HC2-153 | 8.0 × 107 | 5.5 × 1011 | P< .001† |
| Urinary sediment | |||
| Peak* | 5.7 × 107 | 6 × 1012 | P< .001† |
| Total | 7.7 × 108 | 4.9 × 1013 | P< .001† |
| Prior to HC | 7.7 × 108 | 8.6 × 1012 | P< .001† |
| Mean daily prior to HC | 2.3 × 107 | 5.3 × 1011 | P< .001† |
| BK viremia | |||
| Median copies/mL | 2.8 × 104 | 3.8 × 104 | P= NS† |
| ADV viruria (median genome copies/d) | |||
| Free urine | 2.2 × 107 | 7.5 × 107 | P= NS† |
| Urinary sediments | 8.3 × 105 | 8.6 × 105 | P= NS† |
| ADV viremia | |||
| Median genome copies/mL | 2.7 × 104 | 3.3 × 104 | P= NS† |
| Serum creatinine (μmol/L)2-155 | |||
| Median (range) | 81 (50-129) | 73 (53-171) | P = NS† |
| . | No HC . | HC = grade 1 . | HC ≥ grade 2 . | . |
|---|---|---|---|---|
| BK viruria (median genome copies/d) | ||||
| Peak | 5.7 × 107 | 1.1 × 1012 | 1.4 × 1013 | P< .0012-154 |
| Total | 7.7 × 108 | 3.9 × 1012 | 2.5 × 1014 | P< .0012-154 |
| Viruria prior to HC | 7.7 × 108 | 1.4 × 1011 | 2.1 × 1013 | P< .0012-154 |
| Number of patients | ||||
| Daily viruria > 1010/d | 6 | 9 | 6 | |
| Daily viruria < 1010/d | 24 | 5 | 0 |
| . | No HC . | HC = grade 1 . | HC ≥ grade 2 . | . |
|---|---|---|---|---|
| BK viruria (median genome copies/d) | ||||
| Peak | 5.7 × 107 | 1.1 × 1012 | 1.4 × 1013 | P< .0012-154 |
| Total | 7.7 × 108 | 3.9 × 1012 | 2.5 × 1014 | P< .0012-154 |
| Viruria prior to HC | 7.7 × 108 | 1.4 × 1011 | 2.1 × 1013 | P< .0012-154 |
| Number of patients | ||||
| Daily viruria > 1010/d | 6 | 9 | 6 | |
| Daily viruria < 1010/d | 24 | 5 | 0 |
At the day of peaking of BK viruria; total is total viruria during BMT period.
Mann-Whitney test, with NS indicating not significant.
In HC patients, total viruria prior to HC; in non-HC patients, total viruria during BMT.
In non-HC patients, calculated by total viruria/total number of samples collected.
Highest creatinine during the period of HC or BMT.
Kruskal-Wallis test.