Table 2. Characteristics of N- ras codon... | American Society of Hematology

Table 2.

Characteristics of N-ras codon 61 mutations in myeloma

Patient no.	Nucleotide sequence^*	Amino acid substitution^†	% Tumor cells with mutant allele^‡
1	CcA	Proline	12
2	CtA	Leucine	15
3	CgA	Arginine	16
4	CgA	Arginine	18
5	CcA	Proline	18
6	aAA	Lysine	20
7	CcA	Proline	20
8	CcA	Proline	22
9	CtA	Leucine	22
10	aAA	Lysine	24
11	CcA	Proline	26
12	CcA	Proline	28
13	Cat	Histidine	30
14	CgA	Arginine	32
15	CgA	Arginine	32
16	CcA	Proline	34
17	aAA	Lysine	36
18	CtA	Leucine	42
19	CgA	Arginine	44
20	CtA	Leucine	46
21	CAt	Histidine	52
22	CcA	Proline	54
23	CtA	Leucine	64
24	aAA	Lysine	66
25	CtA	Leucine	68
26	CtA	Leucine	70
27	aAA	Lysine	72
28	aAA	Lysine	76
29	CgA	Arginine	82
30	CtA	Leucine	90
31	aAA	Lysine	100
32	CgA	Arginine	100
33	CcA	Proline	100
34	CcA	Proline	100

Patient no.	Nucleotide sequence^*	Amino acid substitution^†	% Tumor cells with mutant allele^‡
1	CcA	Proline	12
2	CtA	Leucine	15
3	CgA	Arginine	16
4	CgA	Arginine	18
5	CcA	Proline	18
6	aAA	Lysine	20
7	CcA	Proline	20
8	CcA	Proline	22
9	CtA	Leucine	22
10	aAA	Lysine	24
11	CcA	Proline	26
12	CcA	Proline	28
13	Cat	Histidine	30
14	CgA	Arginine	32
15	CgA	Arginine	32
16	CcA	Proline	34
17	aAA	Lysine	36
18	CtA	Leucine	42
19	CgA	Arginine	44
20	CtA	Leucine	46
21	CAt	Histidine	52
22	CcA	Proline	54
23	CtA	Leucine	64
24	aAA	Lysine	66
25	CtA	Leucine	68
26	CtA	Leucine	70
27	aAA	Lysine	72
28	aAA	Lysine	76
29	CgA	Arginine	82
30	CtA	Leucine	90
31	aAA	Lysine	100
32	CgA	Arginine	100
33	CcA	Proline	100
34	CcA	Proline	100

Wild-type N-ras codon 61 nucleotide sequence-CAA.

Wild-type amino acid-Gln.

CD138⁺ cells.

Lowercase and bold letters denote nucleotide substitution.