Outcome
| . | Overall (n = 698) . | Age (y) . | P value for trend . | |||||
|---|---|---|---|---|---|---|---|---|
| 0 (n = 57) . | 1 (n = 95) . | 2-4 (n = 140) . | 5-9 (n = 178) . | 10-15 (n = 228) . | Unadjusted . | Adjusted* . | ||
| Complete remission and reasons for failure (%) | ||||||||
| Complete remission | 92 | 89 | 94 | 94 | 90 | 91 | .5 | .5 |
| Induction death | 4 | 11 | 5 | 4 | 3 | 4 | .1 | .06 |
| Resistant disease | 4 | 0 | 1 | 1 | 7 | 5 | .02 | .003 |
| Outcome after remission (actuarial percentage at 5 y) | ||||||||
| Death in remission | 9 | 8 | 8 | 10 | 5 | 11 | 1.0 | .7 |
| Relapse risk | ||||||||
| Any | 37 | 25 | 26 | 41 | 39 | 41 | .02 | .02 |
| BM | 35 | 21 | 22 | 39 | 38 | 39 | .008 | .02 |
| CNS | 2 | 2 | 6 | 3 | 2 | 1 | .05 | .2 |
| Disease-free survival | 58 | 69 | 68 | 53 | 58 | 52 | .04 | .06 |
| Overall outcome (actuarial percentage at 5 y) | ||||||||
| Overall survival | 61 | 65 | 66 | 64 | 60 | 56 | .2 | .02 |
| Event-free survival | 52 | 59 | 63 | 48 | 53 | 47 | .09 | .02 |
| . | Overall (n = 698) . | Age (y) . | P value for trend . | |||||
|---|---|---|---|---|---|---|---|---|
| 0 (n = 57) . | 1 (n = 95) . | 2-4 (n = 140) . | 5-9 (n = 178) . | 10-15 (n = 228) . | Unadjusted . | Adjusted* . | ||
| Complete remission and reasons for failure (%) | ||||||||
| Complete remission | 92 | 89 | 94 | 94 | 90 | 91 | .5 | .5 |
| Induction death | 4 | 11 | 5 | 4 | 3 | 4 | .1 | .06 |
| Resistant disease | 4 | 0 | 1 | 1 | 7 | 5 | .02 | .003 |
| Outcome after remission (actuarial percentage at 5 y) | ||||||||
| Death in remission | 9 | 8 | 8 | 10 | 5 | 11 | 1.0 | .7 |
| Relapse risk | ||||||||
| Any | 37 | 25 | 26 | 41 | 39 | 41 | .02 | .02 |
| BM | 35 | 21 | 22 | 39 | 38 | 39 | .008 | .02 |
| CNS | 2 | 2 | 6 | 3 | 2 | 1 | .05 | .2 |
| Disease-free survival | 58 | 69 | 68 | 53 | 58 | 52 | .04 | .06 |
| Overall outcome (actuarial percentage at 5 y) | ||||||||
| Overall survival | 61 | 65 | 66 | 64 | 60 | 56 | .2 | .02 |
| Event-free survival | 52 | 59 | 63 | 48 | 53 | 47 | .09 | .02 |
BM indicates bone marrow; CNS, central nervous system.
P values adjust for other prognostic factors.