Patient demographics and pretreatment characteristics
| Characteristic . | No. . | % . |
|---|---|---|
| Median age, y (range) | 60 (47-75) | |
| Sex, male/female | 20/10 | 67/33 |
| Karnofsky index | ||
| Less than 80% | 6 | 20 |
| Between 80% and 100% | 24 | 80 |
| Median time since first CLL diagnosis, y (range) | 5 (1-19) | |
| Histological type | ||
| B-CLL | 29 | 97 |
| B-PLL | 1 | 3 |
| Binet stage at study entry | ||
| B | 11 | 37 |
| C | 19 | 63 |
| B symptoms | 14 | 47 |
| Bone marrow infiltration (n = 28) | ||
| Nodular | 13 | 46 |
| Mixed | 6 | 21 |
| Diffuse | 9 | 32 |
| No. of previous treatments for CLL | ||
| 1 | 1 | 3 |
| 2 | 5 | 17 |
| 3 | 8 | 27 |
| 4 | 4 | 13 |
| More than 4 | 12 | 40 |
| Time since end of last CLL treatment | ||
| No more than 12 wk | 10 | 33 |
| 3-6 mo | 6 | 20 |
| 6-12 mo | 8 | 27 |
| 1-2 y | 3 | 10 |
| More than 2 y | 3 | 10 |
| Characteristic . | No. . | % . |
|---|---|---|
| Median age, y (range) | 60 (47-75) | |
| Sex, male/female | 20/10 | 67/33 |
| Karnofsky index | ||
| Less than 80% | 6 | 20 |
| Between 80% and 100% | 24 | 80 |
| Median time since first CLL diagnosis, y (range) | 5 (1-19) | |
| Histological type | ||
| B-CLL | 29 | 97 |
| B-PLL | 1 | 3 |
| Binet stage at study entry | ||
| B | 11 | 37 |
| C | 19 | 63 |
| B symptoms | 14 | 47 |
| Bone marrow infiltration (n = 28) | ||
| Nodular | 13 | 46 |
| Mixed | 6 | 21 |
| Diffuse | 9 | 32 |
| No. of previous treatments for CLL | ||
| 1 | 1 | 3 |
| 2 | 5 | 17 |
| 3 | 8 | 27 |
| 4 | 4 | 13 |
| More than 4 | 12 | 40 |
| Time since end of last CLL treatment | ||
| No more than 12 wk | 10 | 33 |
| 3-6 mo | 6 | 20 |
| 6-12 mo | 8 | 27 |
| 1-2 y | 3 | 10 |
| More than 2 y | 3 | 10 |
PLL indicates prolymphocytic leukemia.