HCV genotypes of the 88 HCV-RNA–positive hemophiliacs and hepatic status
| HCV genotype . | Normal ALT levels, no. (percentage) . | Chronic hepatitis . | Severe liver disease . | All patients . | ||
|---|---|---|---|---|---|---|
| Cirrhosis . | Hepatic decompensation* . | Hepatocellular carcinoma* . | ||||
| 1 | 6 (6.8) | 36 (40.9) | 3 (3.4) | 4 (4.5) | 1 (1.1) | 50 (56.9)† |
| 1a | 4 (4.5) | 12 (13.6) | 2 (2.3) | 1 (1.1) | — | 18 (20.5) |
| 1b | 2 (2.3) | 24 (27.3) | 1 (1.1) | 3 (3.4) | 1 (1.1) | 32 (36.4) |
| 2 | 3 (3.4) | 11 (12.5) | 1 (1.1) | — | — | 15 (17.0) |
| 3 | 3 (3.4) | 10 (11.4) | 1 (1.1) | — | — | 14 (15.9) |
| 4 | 2 (2.3) | 1 (1.1) | — | — | — | 3 (3.4) |
| 1a + 1b | 1 (1.1) | 2 (2.3) | 1 (1.1) | — | 1 (1.1) | 5 (5.7) |
| 1a + 2 | — | 1 (1.1) | — | — | — | 1 (1.1) |
| All patients | 15 (17.0) | 61 (69.3) | 6 (6.8) | 4 (4.5) | 2 (2.3) | 88 (100.0) |
| HCV genotype . | Normal ALT levels, no. (percentage) . | Chronic hepatitis . | Severe liver disease . | All patients . | ||
|---|---|---|---|---|---|---|
| Cirrhosis . | Hepatic decompensation* . | Hepatocellular carcinoma* . | ||||
| 1 | 6 (6.8) | 36 (40.9) | 3 (3.4) | 4 (4.5) | 1 (1.1) | 50 (56.9)† |
| 1a | 4 (4.5) | 12 (13.6) | 2 (2.3) | 1 (1.1) | — | 18 (20.5) |
| 1b | 2 (2.3) | 24 (27.3) | 1 (1.1) | 3 (3.4) | 1 (1.1) | 32 (36.4) |
| 2 | 3 (3.4) | 11 (12.5) | 1 (1.1) | — | — | 15 (17.0) |
| 3 | 3 (3.4) | 10 (11.4) | 1 (1.1) | — | — | 14 (15.9) |
| 4 | 2 (2.3) | 1 (1.1) | — | — | — | 3 (3.4) |
| 1a + 1b | 1 (1.1) | 2 (2.3) | 1 (1.1) | — | 1 (1.1) | 5 (5.7) |
| 1a + 2 | — | 1 (1.1) | — | — | — | 1 (1.1) |
| All patients | 15 (17.0) | 61 (69.3) | 6 (6.8) | 4 (4.5) | 2 (2.3) | 88 (100.0) |
HCV indicates hepatitis C virus; ALT, alanine aminotransferase.
Hepatic decompensation and hepatocellular carcinoma were only observed in patients with established cirrhosis.
Ten of the 56 patients (17.9%) with genotype 1 had a severe liver disease (4 liver cirrhosis, 4 hepatic decompensation, and 2 hepatocellular carcinoma), whereas only 2 of the 32 patients with other genotypes (6.2%) had liver cirrhosis (P < .001).