Table 2.

Characterization of CML patients

Patient no.TherapyBcr-Abl transcripts* (nested PCR)Fusion transcripts (multiplex PCR)Leukocytes (cells/μL)
1 No tolerance of HU and Ara-C (currently w/o therapy) 1.70  × 105 b2a2+ 26 000 
2 IFN 1.27  × 105 b3a2+ NA 
3 IFN + Ara-C 1.70  × 105† b2a2+ NA  
4 PEG IFN → hepatic toxicity 5.48  × 104 b3a2+ 5 800  
5 PEG IFN 2.40  × 105 b3a2+ 51 000  
6 PEG IFN ND ND 6 800  
7 PEG IFN 9.90  × 104 b2a2+/− 11 000  
8 PEG IFN 2.99  × 105 b3a2+ 61 300  
9 PEG IFN + Ara-C 3.97  × 105 b3a2+ 20 600  
10 No tolerance of IFN → PEG IFN → no effect 3.60  × 105 b3a2+ NA  
11 Resistance to IFN → PEG IFN 2.20  × 104 b3a2+ 4 300 
12 No tolerance of IFN → PEG IFN 3.10  × 105 b3a2+ 11 800  
13 HU 6.78  × 104 b2a2+ 10 000  
14 HU 4.03  × 105 b3a2+ 6 900  
15 Busulfan 2.17  × 105 b3a2+ 80 000  
16 CGP57148B (STI571) → no effect 9.03  × 104 b3a2+ 41 000 
Patient no.TherapyBcr-Abl transcripts* (nested PCR)Fusion transcripts (multiplex PCR)Leukocytes (cells/μL)
1 No tolerance of HU and Ara-C (currently w/o therapy) 1.70  × 105 b2a2+ 26 000 
2 IFN 1.27  × 105 b3a2+ NA 
3 IFN + Ara-C 1.70  × 105† b2a2+ NA  
4 PEG IFN → hepatic toxicity 5.48  × 104 b3a2+ 5 800  
5 PEG IFN 2.40  × 105 b3a2+ 51 000  
6 PEG IFN ND ND 6 800  
7 PEG IFN 9.90  × 104 b2a2+/− 11 000  
8 PEG IFN 2.99  × 105 b3a2+ 61 300  
9 PEG IFN + Ara-C 3.97  × 105 b3a2+ 20 600  
10 No tolerance of IFN → PEG IFN → no effect 3.60  × 105 b3a2+ NA  
11 Resistance to IFN → PEG IFN 2.20  × 104 b3a2+ 4 300 
12 No tolerance of IFN → PEG IFN 3.10  × 105 b3a2+ 11 800  
13 HU 6.78  × 104 b2a2+ 10 000  
14 HU 4.03  × 105 b3a2+ 6 900  
15 Busulfan 2.17  × 105 b3a2+ 80 000  
16 CGP57148B (STI571) → no effect 9.03  × 104 b3a2+ 41 000 

HU indicates hydroxyurea; Ara-C, arabinosylcytosine; IFN, interferon-alpha; NA, not available; PEG, pegylated; ND, not detectable (fewer than 103 transcripts); CGP57148B (STI571), Abl kinase inhibitor.

*

Transcripts per microgram RNA.

†

Detected with multiplex PCR.

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