Clinical characteristics of patients with extensive chronic graft-versus-host disease
| . | All patients (n = 68) . | High-risk chronic GVHD (n = 25) . | Low-risk chronic GVHD (n = 43) . |
|---|---|---|---|
| Organ involvement | |||
| Rash/scleroderma | 52 (75%)* | 17 (68%) | 35 (81%) |
| Oral mucositis | 33 (49%) | 8 (32%) | 25 (58%) |
| Ocular sicca | 17 (25%) | 3 (12%) | 14 (33%) |
| Pulmonary disease | 6 (9%) | 0 (0%) | 6 (14%) |
| Liver abnormalities | 45 (66%) | 21 (84%) | 24 (56%) |
| Esophagitis | 3 (4%) | 1 (4%) | 2 (5%) |
| Nausea/vomiting | 10 (15%) | 6 (24%) | 4 (9%) |
| Diarrhea | 20 (29%) | 13 (52%) | 7 (16%) |
| Arthralgias/arthritis | 6 (9%) | 2 (8%) | 4 (9%) |
| Myositis | 2 (3%) | 0 (0%) | 2 (5%) |
| Eosinophilia | 23 (34%) | 3 (12%) | 20 (47%) |
| Effusions | 3 (4%) | 0 (0%) | 3 (7%) |
| Median day of onset after transplantation (range) | Day 209 (90-655) | Day 135 (90-383) | Day 229 (98-655) |
| 1-year progression-free survival from diagnosis of chronic GVHD (95% CI) | 47% (35%-59%) | 16% (0%-30%) | 64% (50%-79%) |
| . | All patients (n = 68) . | High-risk chronic GVHD (n = 25) . | Low-risk chronic GVHD (n = 43) . |
|---|---|---|---|
| Organ involvement | |||
| Rash/scleroderma | 52 (75%)* | 17 (68%) | 35 (81%) |
| Oral mucositis | 33 (49%) | 8 (32%) | 25 (58%) |
| Ocular sicca | 17 (25%) | 3 (12%) | 14 (33%) |
| Pulmonary disease | 6 (9%) | 0 (0%) | 6 (14%) |
| Liver abnormalities | 45 (66%) | 21 (84%) | 24 (56%) |
| Esophagitis | 3 (4%) | 1 (4%) | 2 (5%) |
| Nausea/vomiting | 10 (15%) | 6 (24%) | 4 (9%) |
| Diarrhea | 20 (29%) | 13 (52%) | 7 (16%) |
| Arthralgias/arthritis | 6 (9%) | 2 (8%) | 4 (9%) |
| Myositis | 2 (3%) | 0 (0%) | 2 (5%) |
| Eosinophilia | 23 (34%) | 3 (12%) | 20 (47%) |
| Effusions | 3 (4%) | 0 (0%) | 3 (7%) |
| Median day of onset after transplantation (range) | Day 209 (90-655) | Day 135 (90-383) | Day 229 (98-655) |
| 1-year progression-free survival from diagnosis of chronic GVHD (95% CI) | 47% (35%-59%) | 16% (0%-30%) | 64% (50%-79%) |
Data presented as no. patients (with percentage of group in column in parentheses) unless indicated otherwise.