Attenuation of liver and skin GVHD by WHI-P131 and WHI-P131 + MTX
| Group . | Time of analysis (wk) . | N . | Organ scoring (mean ± SEM) . | |||
|---|---|---|---|---|---|---|
| Liver . | Skin . | Small intestine . | Large intestine . | |||
| A. Syngeneic | 12 | 8 | 0.2 ± 0.1 | 0.0 ± 0.0 | 0.1 ± 0.1 | 0.1 ± 0.1 |
| B. No treatment | 4-6 | 5 | 3.1 ± 0.2 | 2.0 ± 0.2 | 0.9 ± 0.2 | 1.1 ± 0.2 |
| C. Vehicle | 4-6 | 10 | 2.7 ± 0.2 | 1.7 ± 0.1 | 1.1 ± 0.1 | 1.2 ± 0.2 |
| D. WHI-P131 | 4-6 | 8 | 1.6 ± 0.1*(*) | 0.9 ± 0.3*(*) | 0.8 ± 0.1 | 0.7 ± 0.1 |
| E. WHI-P131 | 12 | 3 | 0.7 ± 0.2*(*) | 0.5 ± 0.3*(*) | 0.5 ± 0.0*(*) | 0.6 ± 0.0 |
| F. WHI-P131 + MTX | 12 | 7 | 1.5 ± 0.0*(*) | 0.2 ± 0.1*(*) | 1.1 ± 0.1 | 0.8 ± 0.1 |
| Group . | Time of analysis (wk) . | N . | Organ scoring (mean ± SEM) . | |||
|---|---|---|---|---|---|---|
| Liver . | Skin . | Small intestine . | Large intestine . | |||
| A. Syngeneic | 12 | 8 | 0.2 ± 0.1 | 0.0 ± 0.0 | 0.1 ± 0.1 | 0.1 ± 0.1 |
| B. No treatment | 4-6 | 5 | 3.1 ± 0.2 | 2.0 ± 0.2 | 0.9 ± 0.2 | 1.1 ± 0.2 |
| C. Vehicle | 4-6 | 10 | 2.7 ± 0.2 | 1.7 ± 0.1 | 1.1 ± 0.1 | 1.2 ± 0.2 |
| D. WHI-P131 | 4-6 | 8 | 1.6 ± 0.1*(*) | 0.9 ± 0.3*(*) | 0.8 ± 0.1 | 0.7 ± 0.1 |
| E. WHI-P131 | 12 | 3 | 0.7 ± 0.2*(*) | 0.5 ± 0.3*(*) | 0.5 ± 0.0*(*) | 0.6 ± 0.0 |
| F. WHI-P131 + MTX | 12 | 7 | 1.5 ± 0.0*(*) | 0.2 ± 0.1*(*) | 1.1 ± 0.1 | 0.8 ± 0.1 |
Scoring was performed as described in “Materials and methods.” Statistical analysis of the differences between the WHI-P131–treated and the untreated (vehicle-treated) groups was performed by Student t test;
(*)P < .01.