Effect of matrix metalloproteinases inhibitors on lymphocyte localization inside high endothelial venules
| . | Control . | MMP inhibitor . |
|---|---|---|
| Ro 32-1541 | 1810 ± 1104-150 | 1430 ± 804-150,4-151 |
| TIMP1 | 1150 ± 80‡ | 1240 ± 80‡ |
| . | Control . | MMP inhibitor . |
|---|---|---|
| Ro 32-1541 | 1810 ± 1104-150 | 1430 ± 804-150,4-151 |
| TIMP1 | 1150 ± 80‡ | 1240 ± 80‡ |
MMP indicates matrix metalloproteinase; CFSE, carboxyfluorescein diacetate succidinimidyl ester; HEV, high endothelial venule; LN, lymph node.
Results are mean number of CFSE-labeled cells/mm2 ± SEM inside HEVs and are pooled from brachial and inguinal LNs of 3 mice.
Lower value compared to control mice was also seen in the number of lymphocytes outside HEVs (data not shown), paralleling a lower number of CFSE-labeled cells injected into mice treated with Ro 32-1541.
Results are mean number of CFSE-labeled cells/mm2 ± SEM inside HEVs and are pooled from brachial and inguinal LNs of 4 mice.