Table 1. The IL-4RA Q576R polymorphism... | American Society of Hematology

Table 1.

The IL-4RA Q576R polymorphism in patients with mastocytosis

	P	WT	% P
All patients
Cutaneous	9	4	69.2^*
Systemic	2	21	8.7
ISM	2	16	11.1
AHD	0	5	0
Total	11	25	30.6
Adult onset
Cutaneous	3	1	75^†
Systemic	1	17	5.6
ISM	1	13	7.1
AHD	0	4	0
Total	4	18	18.2
Pediatric onset
Cutaneous	6	3	66.7
Systemic	1	4	20
ISM	1	3	25
AHD	0	1	0
Total	7	7	50

	P	WT	% P
All patients
Cutaneous	9	4	69.2^*
Systemic	2	21	8.7
ISM	2	16	11.1
AHD	0	5	0
Total	11	25	30.6
Adult onset
Cutaneous	3	1	75^†
Systemic	1	17	5.6
ISM	1	13	7.1
AHD	0	4	0
Total	4	18	18.2
Pediatric onset
Cutaneous	6	3	66.7
Systemic	1	4	20
ISM	1	3	25
AHD	0	1	0
Total	7	7	50

P indicates polymorphic; WT, wild type; ISM, indolent systemic mastocytosis; AHD, systemic mastocytosis with an associated nonmast cell hematologic disorder.

P = .0003 versus all systemic, .0014 versus ISM, 0.015 versus AHD.

†

P = .01 versus all systemic, 0.019 versus ISM.

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