White blood cell counts and differentials in wild-type mice (+/+); E-selectin, L-selectin, and P-selectin (E/L/P −/−) null mice; and E-selectin and P-selectin (E/P −/−) null mice
| Variable . | Wild type (+/+) (n = 10) . | E/L/P −/Ün = 10) . | E/P −/Ün = 5) . |
|---|---|---|---|
| WBC count (× 109/L) | 9.99 ± 2.27 | 16.35 ± 4.31* | 33.41 ± 10.99*,† |
| Neutrophils (× 109/L) | 1.05 ± 2.93 | 6.96 ± 3.19* | 15.93 ± 8.53*,† |
| Lymphocytes (× 109/L) | 8.27 ± 1.99 | 7.51 ± 3.09 | 15 ± 2.8*,† |
| Monocytes (× 109/L) | 0.29 ± 0.09 | 0.63 ± 0.12* | 1.33 ± 0.42*,† |
| Eosinophils (× 109/L) | 0.25 ± 0.09 | 0.43 ± 0.21* | 0.45 ± 0.24* |
| Basophils (× 109/L) | 0.04 ± 0.01 | 0.06 ± 0.02 | 0.17 ± 0.06*,† |
| Platelets (× 109/L) | 1066 ± 158 | 1078 ± 900 | 1262 ± 279 |
| Hemoglobin (g/L) | 150 ± 10 | 153 ± 9 | 132 ± 4*,† |
| Hematocrit (%) | 47 ± 2 | 48 ± 2 | 43 ± 0.8*,† |
| Variable . | Wild type (+/+) (n = 10) . | E/L/P −/Ün = 10) . | E/P −/Ün = 5) . |
|---|---|---|---|
| WBC count (× 109/L) | 9.99 ± 2.27 | 16.35 ± 4.31* | 33.41 ± 10.99*,† |
| Neutrophils (× 109/L) | 1.05 ± 2.93 | 6.96 ± 3.19* | 15.93 ± 8.53*,† |
| Lymphocytes (× 109/L) | 8.27 ± 1.99 | 7.51 ± 3.09 | 15 ± 2.8*,† |
| Monocytes (× 109/L) | 0.29 ± 0.09 | 0.63 ± 0.12* | 1.33 ± 0.42*,† |
| Eosinophils (× 109/L) | 0.25 ± 0.09 | 0.43 ± 0.21* | 0.45 ± 0.24* |
| Basophils (× 109/L) | 0.04 ± 0.01 | 0.06 ± 0.02 | 0.17 ± 0.06*,† |
| Platelets (× 109/L) | 1066 ± 158 | 1078 ± 900 | 1262 ± 279 |
| Hemoglobin (g/L) | 150 ± 10 | 153 ± 9 | 132 ± 4*,† |
| Hematocrit (%) | 47 ± 2 | 48 ± 2 | 43 ± 0.8*,† |
Peripheral blood was collected from the retro-orbital sinus of 8-week-old mice and WBC counts and differentials were done by using an automatic cell counter. Values are means ± SD.
WBC indicates white blood cell.
Significant difference (P < 0.05) from wild-type mice (2-tailed Student t test).
Significant difference (P < 0.05) between E/P −/− and E/L/P −/− mice (2-tailed Student t test).