Characteristics of 60 patients whose amyloid IgVL genes were cloned
| Characteristic . | Frequency . |
|---|---|
| Age, y (median [range]) | 55 (29-75) |
| Gender (Men/Women) | 41/19 |
| Median number of organ systems involved (range)* | 2 (1-4) |
| Dominant organ system involved | n (%) |
| Cardiac (≥ NYHA class 2) | 15 (25) |
| Renal | 31 (52) |
| Neuropathic | 5 (8) |
| Hepatic | 5 (8) |
| Other | 4 (7) |
| Plasma cell disorders | n (%) |
| Criteria for myeloma met | 23 (38) |
| Criteria not met | 37 (62) |
| Clonal BM plasma cells (median [range]) | 5-10% (< 5-30) |
| Serum monoclonal protein present | 36 (60) |
| IgGλ | 17 |
| IgGK | 2 |
| IgAλ | 2 |
| IgMλ | 3 |
| λ light chains only | 8 |
| K light chains only | 4 |
| Urine monoclonal protein present | 56 (93) |
| IgGλ | 3 |
| IgAλ | 1 |
| IgGλ + λ light chains | 7 |
| λ light chains | 33 |
| K light chains | 12 |
| Characteristic . | Frequency . |
|---|---|
| Age, y (median [range]) | 55 (29-75) |
| Gender (Men/Women) | 41/19 |
| Median number of organ systems involved (range)* | 2 (1-4) |
| Dominant organ system involved | n (%) |
| Cardiac (≥ NYHA class 2) | 15 (25) |
| Renal | 31 (52) |
| Neuropathic | 5 (8) |
| Hepatic | 5 (8) |
| Other | 4 (7) |
| Plasma cell disorders | n (%) |
| Criteria for myeloma met | 23 (38) |
| Criteria not met | 37 (62) |
| Clonal BM plasma cells (median [range]) | 5-10% (< 5-30) |
| Serum monoclonal protein present | 36 (60) |
| IgGλ | 17 |
| IgGK | 2 |
| IgAλ | 2 |
| IgMλ | 3 |
| λ light chains only | 8 |
| K light chains only | 4 |
| Urine monoclonal protein present | 56 (93) |
| IgGλ | 3 |
| IgAλ | 1 |
| IgGλ + λ light chains | 7 |
| λ light chains | 33 |
| K light chains | 12 |
Organ systems are kidneys, heart, peripheral nervous system, liver, gastrointestinal tract, soft tissues.