Time to maximal temperature reduction of carotid arteries in wild-type mice pretreated with 1B5 Fab, 1B5 F(ab′)2, or control antibodies
| Treatment . | Median time (min) . | Mean time ± SD (min) . | n . | P . |
|---|---|---|---|---|
| Control 9C2 Fab (1 mg/kg) | 7.8 | 7.0 ± 1.5 | 3 | — |
| 1B5 Fab (1 mg/kg) | 12.0 | 12 ± 0.5 | 3 | .2 vs control Fab |
| 1B5 Fab (2 mg/kg) | 21.5 | 19.8 ± 5 | 3 | .006 vs control Fab |
| Control polyclonal F(ab′)2 (1 mg/kg) | 8.7 | 8.8 ± 1.1 | 3 | |
| 1B5 F(ab′)2 (1 mg/kg) | > 30 | > 30 | 3 | < .001 vs polyclonal F(ab′)2 |
| Treatment . | Median time (min) . | Mean time ± SD (min) . | n . | P . |
|---|---|---|---|---|
| Control 9C2 Fab (1 mg/kg) | 7.8 | 7.0 ± 1.5 | 3 | — |
| 1B5 Fab (1 mg/kg) | 12.0 | 12 ± 0.5 | 3 | .2 vs control Fab |
| 1B5 Fab (2 mg/kg) | 21.5 | 19.8 ± 5 | 3 | .006 vs control Fab |
| Control polyclonal F(ab′)2 (1 mg/kg) | 8.7 | 8.8 ± 1.1 | 3 | |
| 1B5 F(ab′)2 (1 mg/kg) | > 30 | > 30 | 3 | < .001 vs polyclonal F(ab′)2 |