Table 1. Sensitivity to carbonyl cyanide... | American Society of Hematology

Table 1.

Sensitivity to carbonyl cyanide m-chlorophenylhydrazone (mCICCP); bcl-2, bax, and bcl-x expression; and p53 status in 16 samples from patients with acute myeloblastic leukemia

Patient no.	mClCCP IC₅₀	Mean bcl2 (BFM × 10⁵)	Mean bax (BFM × 10⁶)	Mean bcl-x (BFM × 10⁵)	p53 status
154R	6	3.1	2.7	6.1	wt
16	10	0.54	1.5	3.9	wt
161	2	0.81	1.2	3.4	wt
145	10	2.0	2.3	5.5	wt
139	4	0.98	0.5	2.4	wt
178	2	4.6	7.8	3.5	wt
179	2	1.4	2.2	2.1	wt
71	4	2.6	2.9	Failed	wt
177	4	1.4	1.8	2.9	wt
71	10	0.54	0.57	1.1	273cgt-cat
136	7	0.29	0.16	0.91	249agg-tgg
157	10	2.3	1.6	1.9	273cgt-cat
95	1	0.66	0.43	1.8	wt
184	11	1.26	2.74	2.2	Not done
134	6	3.1	2.3	1.7	Not done
76	4	2.7	0.97	2.66	Not done

Patient no.	mClCCP IC₅₀	Mean bcl2 (BFM × 10⁵)	Mean bax (BFM × 10⁶)	Mean bcl-x (BFM × 10⁵)	p53 status
154R	6	3.1	2.7	6.1	wt
16	10	0.54	1.5	3.9	wt
161	2	0.81	1.2	3.4	wt
145	10	2.0	2.3	5.5	wt
139	4	0.98	0.5	2.4	wt
178	2	4.6	7.8	3.5	wt
179	2	1.4	2.2	2.1	wt
71	4	2.6	2.9	Failed	wt
177	4	1.4	1.8	2.9	wt
71	10	0.54	0.57	1.1	273cgt-cat
136	7	0.29	0.16	0.91	249agg-tgg
157	10	2.3	1.6	1.9	273cgt-cat
95	1	0.66	0.43	1.8	wt
184	11	1.26	2.74	2.2	Not done
134	6	3.1	2.3	1.7	Not done
76	4	2.7	0.97	2.66	Not done

IC₅₀ indicates the dose of mCICCP which induces 50% loss of mitochondrial membrane potential; BFM, bound fluorochrome molecules.

Correlation coefficients (Spearman ρ for mClCCP IC₅₀ with bcl family expression) were −0.172 for bcl2, 0.178 for bax, and −0.282 for bcl-x; none of these correlations were significant at theP < .05 level.

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