Differences between T- and natural killer–cell type of chronic active Epstein-Barr virus infection
| . | T-cell type (n = 16) . | NK-cell type (n = 12) . | P . |
|---|---|---|---|
| Symptoms | |||
| Fever, > 1 d/wk (%) | 67 | 25 | .04 |
| HMB (%) | 13 | 75 | .002 |
| Splenomegaly (%) | 73 | 100 | .08 |
| Large granular lymphocytosis (%) | 13 | 83 | .0004 |
| Calcification in basal ganglia (%) | 7 | 33 | .10 |
| Laboratory data | |||
| IgG (mg/dL, mean ± SD) | 2213 ± 1104 | 1682 ± 464 | .11 |
| IgE (IU/mL, mean ± SD) | 282 ± 298 | 2774 ± 3774 | .04 |
| VCA IgG (geometric mean titer) | 2405 | 446 | .01 |
| EA IgG (geometric mean titer) | 831 | 119 | .02 |
| EBNA (geometric mean titer) | 30 | 45 | .24 |
| Viral load | |||
| PBMC (copies/μg DNA, mean ± SD) | 104.1±0.5 | 104.4±0.4 | .09 |
| Plasma (copies/mL, mean ± SD) | 102.9±1.1 | 102.4±2.1 | .49 |
| . | T-cell type (n = 16) . | NK-cell type (n = 12) . | P . |
|---|---|---|---|
| Symptoms | |||
| Fever, > 1 d/wk (%) | 67 | 25 | .04 |
| HMB (%) | 13 | 75 | .002 |
| Splenomegaly (%) | 73 | 100 | .08 |
| Large granular lymphocytosis (%) | 13 | 83 | .0004 |
| Calcification in basal ganglia (%) | 7 | 33 | .10 |
| Laboratory data | |||
| IgG (mg/dL, mean ± SD) | 2213 ± 1104 | 1682 ± 464 | .11 |
| IgE (IU/mL, mean ± SD) | 282 ± 298 | 2774 ± 3774 | .04 |
| VCA IgG (geometric mean titer) | 2405 | 446 | .01 |
| EA IgG (geometric mean titer) | 831 | 119 | .02 |
| EBNA (geometric mean titer) | 30 | 45 | .24 |
| Viral load | |||
| PBMC (copies/μg DNA, mean ± SD) | 104.1±0.5 | 104.4±0.4 | .09 |
| Plasma (copies/mL, mean ± SD) | 102.9±1.1 | 102.4±2.1 | .49 |
HMB indicates hypersensitivity to mosquito bites; VCA, viral capsid antigens; EA, early antigens; EBNA, EB nuclear antigens; PBMC, peripheral blood mononuclear cells. Fisher exact test was used to compare symptoms between groups. Student t test was used to compare the mean copy numbers of EBV-DNA or laboratory data. Bold letters indicate statistically significant results.