Table 1. Source and characteristics of... | American Society of Hematology

Table 1.

Source and characteristics of respiration-deficient Chinese hamster fibroblast cell lines

Cell line	Derived from	Defects	Reference
CCLI6-B2	Chinese hamster CCLI6 (DON)	Mutation in X-linked NDUFA1^* gene complex I activity 1%-2% of WT^†	29
CCLI6-B9	Chinese hamster CCLI6 (DON)	Mutation in small integral membrane anchor protein C_II-3 of complex II	30
		Complex II activity less than 5% of WT
Gal32	Chinese hamster V79	Mutation in nuclear gene	31
		Complex IV activity 1%-2% of WT
		Complex I activity 1%-2% of WT
		Defective mitochondrial protein synthesis
V79-G4	Chinese hamster V79	Mutation in nuclear gene on X chromosome	32
		Complex I activity 1%-2% of WT
		Different complementation group to CCLI6-B9
V79-G7	Chinese hamster V79	Mutation in nuclear gene	33
		Complex IV activity 6.6% of WT
		Complex V activity 11.6% of WT
		Defective mitochondrial protein synthesis

Cell line	Derived from	Defects	Reference
CCLI6-B2	Chinese hamster CCLI6 (DON)	Mutation in X-linked NDUFA1^* gene complex I activity 1%-2% of WT^†	29
CCLI6-B9	Chinese hamster CCLI6 (DON)	Mutation in small integral membrane anchor protein C_II-3 of complex II	30
		Complex II activity less than 5% of WT
Gal32	Chinese hamster V79	Mutation in nuclear gene	31
		Complex IV activity 1%-2% of WT
		Complex I activity 1%-2% of WT
		Defective mitochondrial protein synthesis
V79-G4	Chinese hamster V79	Mutation in nuclear gene on X chromosome	32
		Complex I activity 1%-2% of WT
		Different complementation group to CCLI6-B9
V79-G7	Chinese hamster V79	Mutation in nuclear gene	33
		Complex IV activity 6.6% of WT
		Complex V activity 11.6% of WT
		Defective mitochondrial protein synthesis

Human NDUFA1 on the X chromosome encodes the MWFE polypeptide of mammalian complex I.

Wild type.