Table 2.

Intraperitoneal abscess formation following inoculation with Staphylococcus aureus

GroupNNBT (%)Intra-abdominal abscess
WT 33 100 3/33*, 
X-CGD 27 12/27* 
Transplantation chimeras    
 WT/X-CGD 5-10 5/8 
 10 11-20 4/10 
 21-35 0/5 
 35-50 2/5 
 MSCV-m91Neo/X-CGD 5-10 3/4 
 11-20 2/4  
WT Transplants 10 100 0/10 
GroupNNBT (%)Intra-abdominal abscess
WT 33 100 3/33*, 
X-CGD 27 12/27* 
Transplantation chimeras    
 WT/X-CGD 5-10 5/8 
 10 11-20 4/10 
 21-35 0/5 
 35-50 2/5 
 MSCV-m91Neo/X-CGD 5-10 3/4 
 11-20 2/4  
WT Transplants 10 100 0/10 

X-linked chronic granulomatous disease (X-CGD) mice were transplanted with either mixtures of wild-type (WT) and X-CGD bone marrow (BM) or X-CGD BM transduced with MSCV-m91Neo and mock-transduced X-CGD BM. A separate group of WT mice were also transplanted with WT BM. As described in the “Materials and methods” section, WT, X-CGD, and transplanted mice were inoculated by intraperitoneal injection with 2 × 107Staphylococcus aureus, and abscess formation was scored at 1 week.

*

P < .005 Fisher exact test (WT vs X-CGD).

P < .05 Fisher exact test (WT vs WT/X-CGD or MSCV-m91Neo/X-CGD).

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