Laboratory findings of 15 patients with pure red cell aplasia associated with lymphoproliferative disease of granular T lymphocytes
| . | Median (range) . | Normal values . |
|---|---|---|
| Hemoglobin (g/dL) | 7.8 (5.0-10.5) | 12.0-17.5 |
| Mean corpuscular volume (fL) | 90 (83.0-117.9) | 81.2-98.3 |
| White cell count (× 109/L) | 6.6 (3.4-37.0) | 3.5-10.5 |
| Absolute neutrophil count (× 109/L) | 3.09 (0.12-5.41) | 1.70-7.0 |
| Absolute lymphocyte count (× 109/L) | 2.31 (1.06-29.97) | 0.90-2.90 |
| Absolute granular lymphocyte count (× 109/L) | 0.45 (0.30-7.21) | 0.10-0.50 |
| Granular lymphocyte (%) | 31 (10-59) | 5-25 |
| . | Median (range) . | Normal values . |
|---|---|---|
| Hemoglobin (g/dL) | 7.8 (5.0-10.5) | 12.0-17.5 |
| Mean corpuscular volume (fL) | 90 (83.0-117.9) | 81.2-98.3 |
| White cell count (× 109/L) | 6.6 (3.4-37.0) | 3.5-10.5 |
| Absolute neutrophil count (× 109/L) | 3.09 (0.12-5.41) | 1.70-7.0 |
| Absolute lymphocyte count (× 109/L) | 2.31 (1.06-29.97) | 0.90-2.90 |
| Absolute granular lymphocyte count (× 109/L) | 0.45 (0.30-7.21) | 0.10-0.50 |
| Granular lymphocyte (%) | 31 (10-59) | 5-25 |
Clonal T-cell receptor gene rearrangement, 15 of 15 patients; positive direct antiglobulin test, 1 of 10 patients; positive antinuclear antibody test, 4 of 6 patients; rheumatoid factor, 1 of 4 patients; antineutrophil antibody, 0 of 2 patients. Cytogenetic studies, (n = 10 patients). Normal (8); loss of Y chromosome (1); complex abnormality (1). Peripheral blood flow cytometry, (n = 12 patients). CD3+/CD8+ (8); normal (4). Immunophenotypes studied include CD2, CD3, CD5, CD7, CD3/CD8, and CD3/CD4.
Bone marrow immunohistochemistry, (n = 9 patients). Increase in CD3+ and CD8+ cells (9); increase in CD57+ cells (8).