Table 3.

Hematopoietic responses to 21 days of recombinant canine granulocyte-colony stimulating factor treatment after seventh dose of total body irradiation

Hematopoietic parameterElderly dogs median (range)Young dogs median (range)P
Days to maximum ANC 3  (1-20) 4.5  (1-20) .69  
% increases in ANC 331  (128-929) 423  (145-862) .34  
Days of ANC elevation 23  (27-43) 16.5  (6-23) .69  
% increase in CFU-GM in blood on day 9 of rcG-CSF 490  (183-688) 666.5  (334-1010) .20  
% declines in PLT counts3-150 74  (43-94) 89  (77-94) .11 
Hematopoietic parameterElderly dogs median (range)Young dogs median (range)P
Days to maximum ANC 3  (1-20) 4.5  (1-20) .69  
% increases in ANC 331  (128-929) 423  (145-862) .34  
Days of ANC elevation 23  (27-43) 16.5  (6-23) .69  
% increase in CFU-GM in blood on day 9 of rcG-CSF 490  (183-688) 666.5  (334-1010) .20  
% declines in PLT counts3-150 74  (43-94) 89  (77-94) .11 

CFU-GM indicates granulocyte-macrophage colony forming unit; rcG-CSF, recombinant canine granulocyte-colony stimulating factor. See Tables 1 and 2 for other abbreviations.

F3-150

% of PLT count obtained before the last TBI dose and G-CSF treatment.

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