MCL1 transgenic mice develop lymphoma of various subtypes
| Type of disease . | No. cases . | Other sites infiltrated* . |
|---|---|---|
| Disseminated disease | 18 total | |
| Follicular lymphoma | 3† | Liver, lung (2), kidney, bone marrow, GI tract, thymus |
| Composite lymphoma: follicular lymphoma and diffuse large-cell lymphoma | 2 | Liver (2) lung, kidney, GI tract, bone marrow, ovary |
| Diffuse large-cell lymphoma DLBCL (5 cases) DLCL, indeterminate lineage‡ (4 cases) | 9 | Liver (5), kidney (2), lung, bone marrow (2), GI tract (2), ovary |
| Follicular and diffuse polymorphic B cell lymphoma | 4 | Liver (3), kidney (3), lung (3), GI tract, bone marrow, thymus |
| Localized disease | 7 total | |
| Diffuse large-cell lymphoma | 3 | None |
| Polymorphic lymphoma | 2 | None |
| Diffuse small lymphocytic lymphoma | 1 | None |
| T-cell lymphoma | 11-153 | None |
| Type of disease . | No. cases . | Other sites infiltrated* . |
|---|---|---|
| Disseminated disease | 18 total | |
| Follicular lymphoma | 3† | Liver, lung (2), kidney, bone marrow, GI tract, thymus |
| Composite lymphoma: follicular lymphoma and diffuse large-cell lymphoma | 2 | Liver (2) lung, kidney, GI tract, bone marrow, ovary |
| Diffuse large-cell lymphoma DLBCL (5 cases) DLCL, indeterminate lineage‡ (4 cases) | 9 | Liver (5), kidney (2), lung, bone marrow (2), GI tract (2), ovary |
| Follicular and diffuse polymorphic B cell lymphoma | 4 | Liver (3), kidney (3), lung (3), GI tract, bone marrow, thymus |
| Localized disease | 7 total | |
| Diffuse large-cell lymphoma | 3 | None |
| Polymorphic lymphoma | 2 | None |
| Diffuse small lymphocytic lymphoma | 1 | None |
| T-cell lymphoma | 11-153 | None |
GI indicates gastrointestinal; DLBCL, diffuse large B-cell lymphoma; DLCL, diffuse large-cell lymphoma.
The number of mice in which a particular site was involved is indicated in parentheses.
In one mouse, the histopathology could not be definitively distinguished as being follicular lymphoma versus florid hyperplasia.
In tumors of indeterminate origin, immunohistochemistry did not reveal unequivocal staining for either B- or T-cell markers, or was not carried out.
Tumor cells were CD4+CD8+ by flow cytometric assay.