Clinical and laboratory features of the study group at the time of diagnosis
| Feature . | Total (n = 41) . | DS-AMKL (n = 6) . | Secondary AMKL (n = 6) . | De novo AMKL (n = 29) . |
|---|---|---|---|---|
| Median age*(mo) | 23.9 | 25.8 | 113.3 | 21.6 |
| Sex (M:F) | 22:19 | 1:5 | 3:3 | 18:11 |
| Fever | 8 (19.5%) | 0 | 0 | 8 (27.6%) |
| Lymphadenopathy | 12 (29%) | 1 (16.6%) | 0 | 11 (38%) |
| Hepatomegaly | 20 (49%) | 4 (66%) | 0 | 16 (55%) |
| Splenomegaly | 16 (39%) | 2 (33%) | 0 | 14 (48.3) |
| Hemoglobin (g/dL) (median, range) | 9 (4.0-13.8) | 9.2 (4.6-11.4) | 10.0 (4.0-13.8) | 8.8 (5.9-12.8) |
| WBCs (× 109/L) (median, range) | 11.3 (1.1-59.2) | 14.7 (3.7-57.9) | 2.7 (1.1-6.9) | 12.1 (3.3-59.2) |
| Circulating blast cells (%) (median, range) | 15.0 (0-73) | 5.5 (1-66) | 11.5 (0-43) | 16.0 (0-73) |
| Bone marrow blast cells (%) (median, range) | 50.0 (3-100) | 43.5 (16-72) | 41.75 (30-55) | 52.0 (3-100) |
| Platelets (× 109/L) (median, range) | 40.0 (3-528) | 23.5 (6-127) | 184.0 (6-378) | 40.0 (3-528) |
| Serum LDH† (U/L) (median, range) | 1872 (222-9917) | 2857 (510-9917) | 606 (222-996) | 2030 (459-9606) |
| Feature . | Total (n = 41) . | DS-AMKL (n = 6) . | Secondary AMKL (n = 6) . | De novo AMKL (n = 29) . |
|---|---|---|---|---|
| Median age*(mo) | 23.9 | 25.8 | 113.3 | 21.6 |
| Sex (M:F) | 22:19 | 1:5 | 3:3 | 18:11 |
| Fever | 8 (19.5%) | 0 | 0 | 8 (27.6%) |
| Lymphadenopathy | 12 (29%) | 1 (16.6%) | 0 | 11 (38%) |
| Hepatomegaly | 20 (49%) | 4 (66%) | 0 | 16 (55%) |
| Splenomegaly | 16 (39%) | 2 (33%) | 0 | 14 (48.3) |
| Hemoglobin (g/dL) (median, range) | 9 (4.0-13.8) | 9.2 (4.6-11.4) | 10.0 (4.0-13.8) | 8.8 (5.9-12.8) |
| WBCs (× 109/L) (median, range) | 11.3 (1.1-59.2) | 14.7 (3.7-57.9) | 2.7 (1.1-6.9) | 12.1 (3.3-59.2) |
| Circulating blast cells (%) (median, range) | 15.0 (0-73) | 5.5 (1-66) | 11.5 (0-43) | 16.0 (0-73) |
| Bone marrow blast cells (%) (median, range) | 50.0 (3-100) | 43.5 (16-72) | 41.75 (30-55) | 52.0 (3-100) |
| Platelets (× 109/L) (median, range) | 40.0 (3-528) | 23.5 (6-127) | 184.0 (6-378) | 40.0 (3-528) |
| Serum LDH† (U/L) (median, range) | 1872 (222-9917) | 2857 (510-9917) | 606 (222-996) | 2030 (459-9606) |